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张玉涛



张玉涛，特聘副研究员，硕士生导师

邮箱：zhangyutao@ecust.edu.cn

办公地址：上海市徐汇区梅陇路130号，华东理工大学，实验三楼435A

招生专业：化学生物学


教育及工作经历：

2012.09 – 2016.06 华东理工大学 应用化学 本科

2016.09 – 2021.06 华东理工大学 应用化学 博士 （导师：郭志前 教授）

2021.06 – 2024.08 华东理工大学 博士后 （合作导师：朱为宏 院士）

2024.09 – 至今 华东理工大学 化学与分子工程学院 特聘副研究员


研究方向：

主要研究方向包括菁染料类术中导航探针与光激活化学发光探针

围绕术中导航应用开发系列胸导管、胆管、肾损伤、肿瘤实时传感近红外荧光探针；围绕光激活化学发光体系开发氧气浓度、活性氧、酶、以及血脑屏障超高灵敏度传感化学发光探针。已在 J. Am. Chem. Soc.Angew. Chem. Int. Ed., Chem. Sci., Sci. China Chem.等期刊发表研究论文24篇。申请专利6项，授权5项。


主持科研/人才项目：

1、国家自然科学基金面上项目，在研

2、国家自然科学基金青年基金项目C类，在研

3、上海市“超级博士后”激励计划，结题

4、中国博士后科学基金第70批面上项目，结题


代表性论文：

  1. Zhang Y., Li J., Pu R., Chi W., Pan Y., Dong L., Lu Y., Zhao X., Yang J., Yan C., Liu W., Guo Z.*, Zhu W.,Oxygen-driven [2+2] photocycloaddition for in vivo chemiluminescence. J. Am. Chem. Soc. 2026.https://doi.org/10.1021/jacs.6c07700

  2. Yang J.#, Lu Y.#, Zhang Y.*, Zhao X., Li X., Yan C., Zhao Y., Zhu W., Guo Z.*,Sequential H2S-Triggered Redox Relay Nanoprobes for Self-Sustained Chem-Illuminating Cascade Photodynamic Therapy. Angew.Chem. Int. Ed. 2026, 65, e3027612.

  3. Zhang Y., Wu M., Li W., Liu Z., Liu C., Wu Y., Yan C., Xu Y.*, Zhu W.-H., Guo Z.*, Protein-Triggered Reassembly of Quinocyanine Nanosheets for Intraoperative NIR-II Cholangiography. Angew. Chem. Int. Ed.2026, 65, e22772.

  4. Zhang, Y., Yan, C., Zheng, Q., Jia, Q., Wang, Z., Shi, P., Guo, Z. Harnessing Hypoxia-Dependent Cyanine Photocages for In Vivo Precision Drug Release. Angew. Chem. Int. Ed. 2021,60, 9553.

  5. Zhang, Y., Yan, C., Wang, C., Guo, Z., Liu, X., Zhu, W. H. A Sequential Dual-Lock Strategy for Photoactivatable Chemiluminescent Probes Enabling Bright Duplex Optical Imaging. Angew. Chem. Int. Ed. 2020,59, 9059.

  6. Li, J., Zhao, X., Zhang, Y.*, Lu, Y., Xue, H., Li, D., Liu, Q., Yan, C., Chi, W., Xiao, X., Zhu, W.-H., Guo, Z., A two-dimensional fluorescence and chemiluminescence orthogonal probe for discriminating and quantifying similar proteins. Chem. Sci. 2025, 16, 3228.

  7. Zhang Y., Li W., Yu Q., Subinuer M., Shen Y.*, Feng M.*, Guo Z.*, Zhu, W. H. Oral ER-targeting near-infrared nanoprobes enable real-time intraoperative thoracic duct mapping in swine. Sci.China Chem. 2026, 69, 1008–1015.

  8. Zhang, Y., Juan, L., Zhu, W.H., Guo, Z. Sequence-Activated Chemiluminescence Probes: Programmable Il-lumination for High-Contrast in Vivo Sensing and Imaging. Sci. China Chem. 2025, 68, 26.

  9. Zhao, M., Lu Y., Zhang, Y.*, Xue H., Guo, Z.*, Ultra-High Signal-to-noise Ratio Near-Infrared Chemiluminescent Probe for in vivo Sensing Singlet Oxygen. Chin. Chem. Lett. 2025, 36, 110105.

  10. Zhao, Z., Zhang Y.*, Wu M., Yan C., and Guo Z.* A Reversible Dual-Channel Near-Infrared Flavonoid Probe for in Vivo Tracking Glutathione Dynamics in Living Mice. Chem. Biomed. Imaging2023, 1, 620–627.

  11. Lu Y.#, Zhang, Y.#, Xia, W., Pu, R., Yan, C., Liu, W., Liu, X., Guo, Z., Zhu, W.H. A De Novo Zwitterionic Strategy of Ultra-stable Chemiluminescent Probes: Highly Selective Sensing Singlet Oxygen in FDA-approved Phototherapy. Chem. Sci. 2024. 15, 12431.

  12. Xu, Q.#, Zhang, Y.#, Zhu, M., Yan, C., Mao, W., Zhu, W., Guo, Z. Bent-to-Planar Si-Rhodamines: A Distinct Rehybridization Lights up NIR-II Fluorescence for Tracking Nitric Oxide in the Alzheimer's Disease Brain. Chem. Sci. 2023, 14, 4091.

  13. Zhang, L.#, Zhang, Y.#, Chi, W., Yan, C., Zhao, Z., Liu, X., Zhu, W.-H., Guo, Z. “Crossbreeding” Small-Molecular Weight NIR-II Flavchromenes Endows Activatable Multiplexed In Vivo Imaging. ACS Mater. Lett. 2022,4, 1493.


授权专利：

  1. 郭志前; 李娟; 张玉涛; 卢耀; 燕宸旭; 赵美玲; 赵袖妍; 朱为宏. 一种发光探针及其制备方法和应用: ZL202311076428.X. 2024-02-27.

  2.  郭志前; 张玉涛; 沈亚星; 冯明祥; 刘刚; 燕宸旭; 艾中凯; 苏锋; 苏比努尔; 赵美玲; 李温楠; 朱为宏. 一种高亲脂性近红外七甲川菁染料及其制备方法和应用: ZL 2024 1 0247486.2. 2024-04-25.

  3.  郭志前; 朱为宏; 张玉涛; 燕宸旭; 徐清爽; 李娟; 张辽; 王婷; 常茂菊. 一类化学发光强度高、波长长、稳定性好的化学发光底物及其制备方法和应用: ZL 2019 1 0956954.2. 2025-12-12.

  4.  郭志前;张玉涛; 李娟; 卢耀; 燕宸旭; 赵美玲; 刘鹏琦; 朱为宏. 一种单组分有机余辉化合物及其生物检测的应用: ZL202310276502.6. 2026-6-19.

  5. Zhiqian Guo; Juan Li; Yutao Zhang; Yao Lu; Chenxu Yan; Meiling Zhao; Xiuyan Zhao; Weihong Zhu. Luminescent probe and its preparation method and applicationus: US 12,305,098B2. 2025-5-20
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