胡习乐

副教授，硕士生导师，中共党员

Email：xlhu@ecust.edu.cn

研究生招生专业：化学生物学、生物医药

研究团队主页：http://www.xphelab.com/

工作经历

2024.01-至今   华东理工大学，化学与分子工程学院，副教授，硕士生导师

2020.07-2023.12     华东理工大学，化学与分子工程学院，讲师

2017.06-2020.07     华东理工大学，化学与分子工程学院，师资博士后（合作导师：田禾 院士）

学习经历

2012.09-2017.06     华东理工大学，化学与分子工程学院，制药工程与技术，博士（导师：陈国荣教授）

2008.09-2012.06     上海应用技术大学，化学与分子工程学院，应用化学，学士

研究方向

聚焦于生物信息分子识别介导的化学传感器构建与疾病诊疗研究，开展工作如下：

1. 生物识别介导的传感器构建与超级细菌诊断和治疗

2. 工程菌化学修饰与肿瘤细胞诊断和治疗

国家/省部级项目

1. 国家自然科学基金面上项目，2025.01-2028.12，50万，在研，项目负责人。

2. 国家自然科学基金重大研究计划项目（集成项目），2023.01-2025.12，40万，在研，学术骨干。

3. 国家自然科学青年科学基金项目，2020.01-2022.12，25万，已结题，项目负责人。

4. 国家科技重大专项，2018.01-2020.12，44.84万，已结题，子任务负责人。

5. 国家自然科学基金重大研究计划项目，2019.01-2022.12，15万，已结题，学术骨干。

6. 中央高校基本科研业务费青年教师探索研究基金，2018.03-2019.03，16万，已结题，项目负责人。

7. 中国博士后科学基金（一等资助），2018.06-2020.06，8万，已结题，项目负责人。

代表性研究成果：

1. Xi-Le Hu^#, Hui-Qi Gan^#, Wen-Zhen Gui^#, Kai-Cheng Yan, Jonathan L. Sessler*, Dong Yi*, He Tian, and Xiao-Peng He*. Superresolution imaging of antibiotic-induced structural disruption of bacteria enabled by photochromic glycomicelles. PNAS 2024. 121. e2408716121.

2. Xi-Le Hu^#, Hui-Qi Gan^#, Zhao-Yang Qin, Qian Liu, Min Li,* Daijie Chen,* Jonathan L. Sessler,* He Tian and Xiao-Peng He*. Phenotyping of Methicillin-Resistant Staphylococcus aureus Using a Ratiometric Sensor Array. J. Am. Chem. Soc.2023, 145, 8917-8926.

3. Xi-Le Hu^#, Adam C. Sedgwick^#*, Daniel N. Mangel^#, Ying Shang, Axel Steinbrueck, Kai-Cheng Yan, Ling Zhu, Dylan W. Snelson, Sajal Sen, Calvin V. Chau, Gabriel Juarez, Vincent M. Lynch, Xiao-Peng He*, and Jonathan L. Sessler*. Tuning the Solid- and Solution-State Fluorescence of the Iron-Chelator Deferasirox. J. Am. Chem. Soc.2022, 144, 7382-7390. 

4. Xi-Le Hu^#, Nahyun Kwon^#, Kai-Cheng Yan, Adam C. Sedgwick, Guo-Rong Chen, Xiao-Peng He*, Tony D James*, and Juyoung Yoon*. Bio-Conjugated Advanced Materials for Targeted Disease Theranostics. Adv. Funct. Mater.2020, 30, 1907906. 

5. Xi-Le Hu, Linyang Chu, Xiaojing Dong, Guo-Rong Chen, Tingting Tang, Daijie Chen*, Xiao-Peng He*, and He Tian. Multivalent Glycosheets for Double Light-Driven Therapy of Multidrug-Resistant Bacteria on Wounds. Adv. Funct. Mater.2019, 29, 1806986. 

6. Xi-Le Hu^#, Quanyu Cai^#, Jie Gao^#, Robert A. Field, Guo-Rong Chen, Ningyang Jia*, Yi Zang*, Jia Li*, and Xiao-Peng He*. Self-Assembled 2D Glycoclusters for the Targeted Delivery of Theranostic Agents to Triple-Negative Breast Cancer Cells. ACS Appl. Mater. Interfaces.2019, 11, 22181-22187. 

7. Chao Zhang^#, De-Tai Shi^#, Kai-Cheng Yan^#, Adam C. Sedgwick, Guo-Rong Chen, Xiao-Peng He, Tony D. James, Bing Ye*,Xi-Le Hu* and Daijie Chen*. A glycoconjugate-based gold nanoparticle approach for the targeted treatment of Pseudomonas aeruginosa biofilms†. Nanoscale2020, 12, 23234-23240.

8. Jin-Biao Jiao^#, Guan-Zhen Wang^#, Xi-Le Hu^#, Yi Zang, Séphane Maisonneuve, Adam C. Sedgwick, Jonathan L. Sessler*, Juan Xie*, Jia Li*, Xiao-Peng He*, and He Tian. Cyclodextrin-based Peptide Self-Assemblies (Spds) that Enhance Pep-tide-based Fluorescence Imaging and Antimicrobial Efficacy.J. Am. Chem. Soc. 2020, 142, 1925-1932. 

9. Ying Shang^#, Sheng Zhang^#, Hui-Qi Gan^#, Kai-Cheng Yan, Fugui Xu, Yiyong Mai, Daijie Chen, Xi-Le Hu*, Lei Zou*, Tony D. James *and Xiao-Peng He *. Targeted photothermal release of antibiotics by a graphene nanoribbon-based supramolecular glycomaterial†. Chem. Commun. 2023, 59, 1094-1097.

10. Xi-Le Hu, Hui-Qi Gan, Fan-De Meng, Hai-Hao Han, De-Tai Shi, Shu Zhang, Lei Zou, Xiao-Peng He, Tony D. James. Fluorescent probes and functional materials for biomedical applications. Front. Chem. Sci. Eng.2022, 16, 1425-1437.

11. Ming Zhou^#, Hui-Qi Gan^#, Guo-Rong Chen, Tony D James, Bin Zhang, Qiang Hu*, Fugui Xu*, Xi-Le Hu*, Xiao-Peng He and Yiyong Mai. Near-Infrared Light-Triggered Bacterial Eradication Using a Nanowire Nanocomposite of Graphene Nanoribbons and Chitosan-Coated Silver Nanoparticles. Front. Chem.2021, 9, 767847.

12. Xi-Le Hu^#, Ying Shang^#, Kai-Cheng Yan^#, Adam C. Sedgwick, Hui-Qi Gan, Guo-Rong Chen, Xiao-Peng He*, Tony D. James* and Daijie Chen*. Low-dimensional nanomaterials for antibacterial applications. J. Mater. Chem. B. 2021, 9, 3640-3661.

13. Linyang Chu, Guoqiang Jiang, Xi-Le Hu*, Tony D. James, Xiao-Peng He, Yaping Li* and Tingting Tang*. Osteogenesis, vascularization and osseointegration of a bioactive multiphase macroporous scaffold in the treatment of large bone defects. J. Mater. Chem. B. 2018, 6, 4197-4204.