李自远
特聘副研究员 硕士生导师
办公室：徐汇校区 实验十三楼308
邮 箱：ziyuan.li@ecust.edu.cn
招生专业：精细合成化学与分子工程, 化学生物学（硕士）
工作经历
2010年9月--2014年7月，天津大学，化工学院，学士
2014年9月--2019年6月，华东理工大学，化学与分子工程学院，博士（导师：田禾 院士）
2017年10月--2018年12月，以色列耶路撒冷希伯来大学，联合培养博士（导师：Itamar Willner 院士）
2019年7月--2022年11月，华东理工大学，化学与分子工程学院，博士后（合作导师：田禾 院士）
2022年12月--至今，华东理工大学，化学与分子工程学院，特聘副研究员
研究方向
主要研究方向为光响应水凝胶生物医用材料创制，聚焦功能水凝胶在动态化学、材料、生物医学交叉领域的应用研究，围绕“水凝胶粘弹性高时空分辨调控，实现与生物组织精准适配”这一关键科学问题，开展了系统性研究工作：
1、仿生凝胶材料构建：基于光响应等功能分子灵活构建系列响应性水凝胶，实现凝胶粘弹性仿生及可控
2、细胞行为及命运调控：发展时空动态适配型水凝胶细胞调控平台，实现细胞凋亡和迁移等行为的智能可控
3、创伤修复与组织再生：基于粘弹性动态适配理念构建凝胶敷料用于多类型创面快速修复及缺损组织功能重建
至今已发表论文10余篇，其中第一/共一作者发表论文8篇，包括J. Am. Chem. Soc. 1篇，Angew. Chem. Int. Ed. 1篇，CCS Chem. 1篇等等。申请中国发明专利3项。
国家/省部级项目
1）国家自然科学基金委-青年基金项目，22105070，30万，主持，2022.01-2024.12
2）科技创新行动计划扬帆计划，20YF1410300，20万，主持，2020.07-2023.06
3）中国博士后科学基金面上资助，2020M671017，8万，主持，2020.09-2022.09
论文与专著
论文：
1. Ziyuan Li, # Xiaojie Zhang#, Yiming Gao#, Yanyan Song, Shuangbai Zhou*, Qingfeng Li*, Junji Zhang*. Photo-responsive hydrogel for contactless dressing change to attenuate secondary damage and promote diabetic wound healing. Adv. Healthcare Mater.2023, 2202770.
2. Yiming Gao#, Ziyuan Li#, Xiaojie Zhang, Junji Zhang*, Qingfeng Li*, Shuangbai Zhou*. One-pot synthesis of bioadhesive double-network hydrogel bandage as disposable wound dressing. ACS Appl. Mater. Interfaces2023, 15, 11496-11506.
3. Ziyuan Li, Yanzi Zhou, Tianyue Li, Junji Zhang*, He Tian. Stimuli-responsive hydrogels: Fabrication and biomedical applications. VIEW2022, 3, 20200112.
4. Chen Wang, Michael P. O’Hagan, Ziyuan Li, Junji Zhang, Xiang Ma, He Tian, Itamar Willner*. Photoresponsive DNA materials and their applications. Chem. Soc. Rev.2022, 51, 720-760.
5. Ziyuan Li#, Yingya Liu#,Yuanjie Li, Wenhui Wang, Yanyan Song, Junji Zhang*, He Tian. High-preservation single-cell operation through a photo-responsive hydrogel-nanopipette system. Angew. Chem. Int. Ed.2020, 60, 5157-5161.
6. Ziyuan Li#, Chen Wang#, Jiang Li#, Junji Zhang*, Chunhai Fan, Itamar Willner*. Functional DNA structures and their biomedical applications. CCS Chem.2020, 2, 707-728.
7. Ziyuan Li, Verena Wulf, Chen Wang, Margarita Vazquez-Gonzalez, Michael Fadeev, Junji Zhang*, He Tian, Itamar Willner*. Molecularly imprinted sites translate into macroscopic shape-memory properties of hydrogels. ACS Appl. Mater. Interfaces2019, 11, 34282-34291.
8. Jianbang Wang, Liang Yue, Ziyuan Li, Junji Zhang, He Tian, Itamar Willner*. Active generation of nanoholes in DNA origami scaffolds for programmed catalysis in nanocavities. Nat. Commun.2019, 4963.
9. Xia Liu#, Junji Zhang#, Michael Fadeev, Ziyuan Li, Verena Wulf, He Tian, Itamar Willner*. Chemical and photochemical DNA “gears” reversibly control stiffness, shape-memory, self-healing and controlled release properties of polyacrylamide hydrogels. Chem. Sci.2019, 10, 1008-1016.
10. Ziyuan Li, Gilad Davidson-Rozenfeld, Margarita Vazquez-Gonzalez, Michael Fadeev, Junji Zhang*, He Tian, Itamar Willner*. Multi-triggered supramolecular DNA/bipyridinium dithienylethene hydrogels driven by light, redox, and chemical stimuli for shape-memory and self-healing applications. J. Am. Chem. Soc.2018, 140, 17691-17701.
11. Yilun Ying, Ziyuan Li, Zhengli Hu, Junji Zhang*, Funa Meng, Chan Cao, Yitao Long*, He Tian, A Time-resolved single molecular train based on aerolysin nanopore. Chem (Cell press), 2018, 4, 1893.
12. Zhengli Hu, Ziyuan Li, Yilun Ying*, Junji Zhang, Chan Cao, Yitao Long, He Tian. Real-time and accurate identification of single oligonucleotide photoisomers via an aerolysin nanopore. Anal. Chem.2018, 90, 4268-4272.
13. Shan Wang, Liang, Yue, Ziyuan Li, Junji Zhang, He Tian, Itamar Willner*. Light-induced reversible reconfiguration of DNA-based constitutional dynamic networks: application to switchable catalysis. Angew. Chem., Int. Ed.2018, 57, 8105-8109.
14. Funa Meng#, ZiyuanLi#, Yilun Ying*, Shaochuang Liu, Junji Zhang, Yitao Long, Structural stability of the photo-responsive DNA duplexes containing one azobenzene via a confined pore. Chem. Commun. 2017, 53, 9462-9465.