国家杰出青年科学基金项目获得者。科技部重点研发项目“合成生物学专项”项目负责人。研究员，博士生导师
联系方式
手机：15133505336
Email: dahan@sjtu.edu.cn
个人简介
单位：上海交通大学医学院分子医学研究院
职务：研究员
教育经历
2009年8月-2013年12月，美国佛罗里达大学，化学系，博士 博士导师：谭蔚泓
2005年9月-2009年7月，中国厦门大学，化学系，学士
科研与学术经历
2018年6月-至今，上海交通大学医学院分子医学研究院，研究员
2014年2月-2018年5月，美国Intel公司，高级制程研发工程师。
2009年8月-2013年12月，美国佛罗里达大学，化学系，研究助理。
研究方向
核酸化学与核酸纳米技术
靶向蛋白降解与疾病治疗
生物传感与液体活检
研究成果和学术奖励
代表性研究论文列表:
[1]. Chao Zhang, Tingting Zheng, Qian Ma, Linlin Yang, Mingzhi Zhang, Junyan Wang, Xiaoyan Teng, Yanyan Miao, Hsiao-chu Lin, Yang Yang*, Da Han*. Logical Analysis of Multiple Single-Nucleotide-Polymorphisms with Programmable DNA Molecular Computation for Clinical Diagnostics. Angew. Chem. Int. Ed., 2022, 61, e202117658.
[2]. Yumeng Zhao#, Chao Zhang#, Linlin Yang, Xuemei Xu, Rui Xu, Qian Ma, Qian Tang, Yang Yang, Da Han*. Programmable and Site-Specitic Patterning on DNA Origami Templates with Heterogeneous Condensation of Silver and Silica. Small, 2021, 17, 2103877
[3]. Yanyan Miao#, Qianqian Gao#, Menghan Mao, Chao Zhang, Liqun Yang, Yang Yang, Da Han*. Bispecific Aptamer Chimeras Enable Targeted Ptrotein Degradation on Cell Membranes. Angew. Chem. Int. Ed., 2021, 60(22): 11267-11271.
[4]. Chao Zhang#, Tingting Zheng#, Hua Wang, Wei Chen, Xiaoye Huang, Jianqi Liang, Liping Qiu, Da Han*, Weihong Tan*. Rapid One-Pot Detection of SARS-CoV-2 Based on a Lateral Flow Assay in Clinical Samples. Analytical Chemistry, 2021, 93(7): 3325-3330
[5]. Yike Li, Jinqi Deng, Ziwei Han, Chao Liu, Fei Tian, Rui Xu, Da Han*, Shaohua Zhang*, Jiashu Sun*. Molecular Identification of Tumor-Derived Extracellular Vesicles Using Thermophoresis-Mediated DNA computation. Journal of the American Chemistry Society, 2021, 143(3): 1290-1295.
[6]. Chao Zhang, Yumeng Zhao, Xuemei Xu, Rui Xu, Haowen Li, Xiaoyan Teng, Yuzhen Du, Yanyan Miao, Hsiao-chu Lin, Da Han*. Cancer Diagnosis with DNA Molecular Computation. Nature Nanotechnology, 2020, 15: 709-715.
[7]. Qianqian Gao#, Yumeng Zhao#, Kangli Xu, Chao Zhang, Qian Ma, Liqing Qi, Dandan Chao, Tingting Zheng, Linlin Yang, Yanyan Miao, Da Han*. Highly Specific, Single-step Cancer Cell Isolation With Multi-Aptamer-Mediated Proximity Ligation on Live Cell Membranes. Angew. Chem. Int. Ed. 2020, 59(52): 23564-23568.
[8]. Linlin Yang, Yumeng Zhao, Xuemei Xu, Kangli Xu, Mingzhi Zhang, Kui Huang, Huaizhi Kang*, Hsiao-chu Lin, Yang Yang*, Da Han*. An intelligent DNA nanorobot for autonomous anticoagulation. Angew. Chem. Int. Ed. 2020, 59(40): 17697-17704.
[9]. Cheng Lv#, Xiyao Gu#, Haowen Li, Yumeng Zhao, Donglei Yang, Weifeng Yu*, Da Han*, Juan Li, Weihong Tan*. Molecular Transport through a Biomimetic DNA Channel on Live Cell Membranes. ACS Nano, 2020, 14,11: 14616-14626.
[10]. Da Han, Juan Li, Weihong Tan. CRIPSR Propels a Smart Hydrogel. Science, 2019, 365(6455): 754-755.
[11]. Xu Chang, Chao Zhang, Cheng Lv, Yang Sun, Mingzhi Zhang, Yumeng Zhao, Linlin Yang, Da Han*, Weihong Tan*. Construction of a Multitple-aptamer-based DNA Logic Device on Live Cell Membranes via Associative Toehold Activation for Accurate Cancer Cell Identification. Journal of the American Chemistry Society, 2019, 141(32): 12738-12743.
[12]. Linlin Yang, Lingyan Meng, Jiaying Song, Yue Xiao, Ruowen Wang, Huaizhi Kang* and Da Han *. Dynamic Colloidal Nanoparticle Assembly Triggered by Aptamer-receptor Interactions on Live Cell Membranes. Chemical Science, 2019, 10, 7466-7471.
[13]. Ding Ding, Da Han, Juan Li and Weihong Tan. Improving Early Detection of Cancers by Profiling Extracellular Vesicles, Expert Review of Proteomics, 2019, 16, 545-547.
[14]. Yumeng Zhao and Da Han*. Nucleic Acid Based Intelligent Systems and Their Biomedical Applications. SCIENTIA SINICA Chimica (中国科学:化学), 2019, 62,1-7.
[15]. Yifan Lyu, Cuichen Wu, Charles Heinke, Da Han*, Ren Cai, I-Ting Teng, Yuan Liu, Hui Liu, Xiao-Bing Zhang, Qiaoling Liu, Weihong Tan*. Constructing smart protocells with built-in DNA computational core to eliminate exogenous challenge. J. Am. Chem. Soc. 140, 22, 6912-6920
[16]. Mingxu You#, Yifan Lv#, Da Han# (Co-first author), Liping Qiu, Qiaoling Liu, Tao Chen, Cuicheng Wu, Lu Peng, Liqin Zhang, Gang Bao and Weihong Tan. DNA Probe Signals Rapid Molecular Encounter Dynamics on Live Cell Membranes. Nature Nanotechnology, 2017, 12(5), 453-460
[17]. Da Han#, Cuichen Wu#, Mingxu You#, Tao Zhang, Shuo Wan, Tao Chen, Liping Qiu, Zheng Zheng, Hao Liang, and Weihong Tan. A Cascade Reaction Network Mimicking the Basic Functional Steps of Acquired Immune Response. Nature Chemistry, 2015, 7(10),835-841
[18]. Da Han, Guizhi Zhu, Cuichen Wu, Zhi Zhu, Tao Chen, Xiaobing Zhang and Weihong Tan. Engineering a Cell-Surface Aptamer Circuit for Targeted and Amplified Photodynamic Cancer Therapy. ACS Nano, 2013,7,2312-2319
[19]. Da Han, Huaizhi Kang, Tao Zhang, Cuichen Wu, Cuisong Zhou, Mingxu You, Zhuo Chen, Xiaobing Zhang, Weihong Tan. Nucleic Acid Based Logical Systems (Concept paper), Chemistry-A European Journal, 2014,20, 5866-5873.
[20]. Da Han, Zhi Zhu, Cuichen Wu, Lu Peng, Leiji Zhou, Basri Gulbakan, Guizhi Zhu, Kathryn Williams, Weihong Tan. A logical molecular circuit for programmable and autonomous regulation of protein activity using DNA aptamer-protein interactions. Journal of the American Chemical Society, 2012, 134,20797-20804.
[21]. Da Han, Jin Huang, Zhi Zhu, Quan Yuan, Mingxu You, Yan Chen and Weihong Tan. Molecular engineering of photoresponsive three-dimensional DNA nanostructures. Chemical Communications, 2011, 47, 4670-4672.
[22]. Cuichen Wu#, Da Han# (Co-first author), Tao Chen, Lu Peng, Guizhi Zhu, Mingxu You, Liping Qiu, Kwame Sefah, Xiao-Bing Zhang, Weihong Tan. Building a Multifunctional Aptamer-Based DNA Nanoassembly for Targeted Cancer Therapy. Journal of the American Chemical Society, 2013, 135, 18644-18650.
[23]. Pu Ying#, Zhi Zhu#, Da Han# (Co-first author), Huixia Liu, Jun Liu, Jie Xia, Kejing Zhang and Weihong Tan. Insulin-binding aptamer-conjugated graphene oxide for insulin detection. Analyst, 2011,136, 4138-4140.
书籍著作
[1]. Da Han, Chaoyong Yang and Weihong Tan. Functional materials for signal amplification of molecular beacons. In: Molecular Beacons, Springer, Heidelberg, 2011.
[2]. Da Han and Weihong Tan.Molecular Engineering to Enhance Aptamer Functionality. In: Aptamers Selected by Cell SELEX for Theranostics, Springer, 2015.
奖励
2021九龙青年医学奖
2020中国化学会青年化学奖
2020中国化学会菁青化学新锐奖
2020上海市科技青年启明星
2012 Roger G. Bates and Herbert A. Laitinen 研究生奖学金
2012年获美国化学会分析化学优秀研究生奖