王鹏飞

王鹏飞

国家海外高层次人才青年项目

研究员博士生导师

办公室：上海市浦东新区浦建路160号17号楼1619

邮箱：pengfei.wang@sjtu.edu.cn

工作经历

2003年--2007年，天津大学，材料科学与工程，学士

2007年--2009年，天津大学，材料科学与工程，硕士（导师：刘文广）

2009年--2014年，美国普渡大学，生物医学工程，博士（导师：Chengde Mao）

2014年6月--2018年8月，美国埃默里大学医学院，博士后

2018年9月--至今，上海交通大学医学院，研究员，博士生导师

2022年--至今，华东理工大学，化学与分子工程学院，兼聘导师

研究方向

· 分子自组装

· 生物材料

· 分子诊断

· 疾病诊疗

科研项目

1. 科技部重点研发计划，2021/12-2026/11，主持

2. 国家自然科学基金中德国际合作项目，2021/01-2023/12，主持

3. 国家自然科学基金面上项目，2020/01-2023/12，主持

4. 第十四批“海外高层次人才”青年项目，主持

5. 科技部重点研发计划，2019/07-2024/06，，参与

论文与专著

专著：

1. Y. Ke and P. Wang. 3D DNA Nanostructure: Methods and Protocols. Methods in Molecular Biology, Springer, 2016. (Book Editor)

代表性论文：

1. C. Zhou, D. Yang, S. Sensale, P. Sharma, D. Wang, L. Yu, G. Arya, Y. Ke* and P. Wang*. A bistable and reconfigurable molecular system with encodable bonds. Sci. Adv., In press.

2. M. Wang, D. Yang, Q. Lu, L. Liu, Z. Cai, Y. Wang, H. Wang, P. Wang* and Z. Nie*. Spatially Reprogramed Receptor Organization to Switch Cell Behaviors using DNA Origami-Templated Aptamer Nanoarray. Nano Lett., 2022.

3. X. Ma, J. Xu, F. Zhou, J. Ye, D. Yang, H. Wang*, P. Wang* and M. Li*. Recent Advances in PCR-Free Nucleic Acid Detection for SARS-Cov-2. Front. Bioeng. Biotechnol., 2022.

4. X. Yang, L. Yang, D. Yang, M. Li* and P. Wang*. In Situ DNA Self-Assembly on the Cell Surface Drives Unidirectional Clustering of Membrane Proteins for the Modulation of Cell Behaviors. Nano Lett., 22, 3410-3416,2022.

5. F. Gao, D. Yang, F. Xu, X. Ma and P. Wang*. Promoting Cell Fusion by Polyvalent DNA Ligands. Nano Lett., 22, 3018-3025, 2022.

6. D. Yang and P. Wang*. A DNA-Based Molecular System That Can Autonomously Add and Extract Components. ACS Appl. Mater. Interfaces, 13, 41004-41011, 2021.

7. F. Xu^#, B. Dong^#, X. Li, F. Gao, D. Yang, W. Xue and P. Wang*. Profiling and Regulating Proteins that Adsorb to DNA Materials in Human Serum. Anal. Chem., 93, 8671-8679, 2021.

8. X. Li, F. Xu, D. Yang and P. Wang*. A DNA-binding, albumin-targeting fusion protein promotes the cellular uptake and bioavailability of framework DNA nanostructure. Nanoscale, 2021, 13, 6038-6042, 2021

9. P. Wang*, J. Huh#, H. Park, D. Yang, K. Park, Y. Zhang, Y. Zhang, J. Lee, S. Lee* and Y. Ke*. DNA Origami Guided Self-Assembly of Plasmonic Polymers with Robust Long-Range Plasmonic Resonance. Nano Lett., 20, 8926-8932, 2020.

10. F. Xu, Q. Xia and P. Wang*. Rationally Designed DNA Nanostructures for Drug Delivery. Front. Chem., 8, 751, 2020.

11. Nanoparticle Nanoclusters and Lattices. J. Mater. Chem. B, 8, 6810-6813, 2020.

12. C. Zhou, Y. Yang, H. Li, F. Gao, C. Song, D. Yang, F. Xu, N. Liu, Y. Ke, S. Su* and P. Wang*. Programming Surface-Enhanced Raman Scattering of DNA Origami-templated Metamolecules. Nano Lett., 20, 3155-3159, 2020.

13. D. Yang, C. Zhou, F. Gao, P. Wang* and Y. Ke. DNA-Guided Assembly of Molecules, Materials, and Cells. Adv. Intell. Syst., 2,1900101, 2020.

14. Y. Zhang*, X. Chen, G. Kang, R. Peng, V. Pan, R. Sundaresan, P. Wang* and Y. Ke*. Programming DNA Tube Circumference by Tile Offset Connection. J. Am. Chem. Soc., 141, 19529-19532, 2019.

15. C. Zhou, H. Geng, P. Wang* and C. Guo*. Programmable DNA Nanoindicator-Based Platform for Large-Scale Square Root Logic Biocomputing. Small, 1903489, 2019.

16. P. Wang*,J. Huh,J. Lee,K. Kim, K. Park, S. Lee*and Y. Ke*. Magnetic Plasmon Networks Programmed by Molecular Self-Assembly. Adv. Mater., 31, 1901364, 2019.

17. Y. Zhang*, V. Pan, X. Li, X. Yang, H. Li, P. Wang* and Y. Ke*. Dynamic DNA Structures. Small, 15, 1900228, 2019.

18. P. Wang* and Y. Ke*. Attack on the Cell Membrane: The Pointy Ends of DNA Nanostructures Lead the Way. ACS Cent. Sci., 4, 1298-1299, 2018.

19. P. Wang,M.A. Rahman,Z. Zhao, K. Weiss, C. Zhang, Z. Chen, S.J. Hurwitz, Z.G. Chen, D.M. Shin and Y. Ke. Visualization of the Cellular Uptake and Trafficking of DNA Origami Nanostructures in Cancer Cells. J. Am. Chem. Soc., 140, 2478-2484, 2018.

20. P. Wang, T.A. Meyer, V. Pan, P. Dutta and Y. Ke. The Beauty and Utility of DNA Origami. Chem, 2, 358-382, 2017.

21. M.A. Rahman, P. Wang,Z. Zhao,D. Wang, S. Nannapaneni, C. Zhang, Z. Chen, C.C. Griffith, S.J. Hurwitz, Z.G. Chen, Y. Ke and D.M. Shin. Systemic Delivery of Bcl-2 Targeting siRNA by DNA Nanoparticle suppresses Cancer Cell Growth. Angew. Chem. Int. Ed., 56, 16023-16027, 2017.

22. L. Ong, N. Hanikel, O. Yaghi, C. Grun, M. Strauss, P. Bron, J. Lai-Kee-Him, F. Schueder, B. Wang, P. Wang, J. Kishi, C. Myhrvold, A. Zhu, R. Jungmann, G. Bellot, Y. Ke and P. Yin. Programmable Self-assembly of Three-Dimensional Nanostructures from 10,000 Unique Components. Nature, 52, 72-77, 2017.

23. J. Song, Z. Li, P. Wang, T.A. Meyer, C. Mao and Y. Ke. Reconfiguration of DNA Molecular Arrays Driven by Information Relay. Science, 357, eaan3377, 2017.

24. P. Wang,S. Wu,C. Tian, G. Yu, W. Jiang, G. Wangand C. Mao. Retrosynthetic Analysis-Guided Breaking Tile Symmetry for Assembly of Complex DNA Nanostructures. J. Am. Chem. Soc., 138, 13579-13585, 2016.

25. P. Wang, S. Gaitanaros, S. Lee, M. Bathe,W. Shih and Y. Ke. Programming Self-Assembly of DNA-Origami Honeycomb Two-Dimensional Lattices and Plasmonic Metamaterials. J. Am. Chem. Soc., 138, 7733-7740, 2016.

26. P. Wang, C. Tian, X. Li and C. Mao. Assembly of Barcode-like Nucleic Acid Nanostructures. Small, 10, 3923-3926, 2014.

27. P. Wang, S.K. Ko, C. Tian, C. Hao and C. Mao. RNA-DNA hybrid origami: Folding of A Long RNA Single Strand into Complex Nanostructures Using Short DNA Helper Strands. Chem. Commun., 49, 5462-5464, 2013.

28. P. Wang, H. Jaganathan and A. Ivanisevic. Multi-component DNA-templated Nanoparticle Chains with Controllable Dimension and Composition. Small, 7, 2021-2026, 2011.