王若文

王若文

上海交通大学医学院研究员

癌基因与相关基因国家重点实验室课题组长。

办公室：东方路1630号仁济医院科研楼1819

电子邮箱：wangwrw@sjtu.edu.cn。

招生专业：

工作经历

2017.10-至今，上海交通大学医学院分子医学研究院，研究员，PI

2015.6 – 2017.9，浙江清华长三角研究院，PI

2013.7 – 2017.9，湖南大学化学化工学院，客座研究员

2011.7 – 2013.6，上海有机化学研究所，副研究员

2009.5 – 2011.4，佛罗里达大学化学系，博士后，合作导师：谭蔚泓教授

2006.9 – 2009.4，匹茨堡大学药学院，博士后，合作导师：Barry Gold教授

2003.9 – 2006.6，上海有机化学研究所，博士，合作导师：卿凤翎研究员

2000.9 – 2003.3，东华大学应用化学系，硕士，合作导师：卿凤翎研究员

1994.9 – 1998.6，湖南大学化学化工学院，学士

研究方向:

非天然碱基、功能核酸与药物递送技术研究：主要开展功能型碱基的设计与合成、核酸适体-药物偶联物的模块化构建及基于核酸分子的靶向递送研究。

省部级科研项目：

国家自然科学基金面上项目, 基于核酸适体的靶向性组合药物体系构建研究及肿瘤耐药性调控, 2019.1-2022.12

浙江省自然科学基金面上项目，疏水作用在核酸参与自组装过程中的机制研究，2016.1-2018.12

科技部, 合成生物学重点专项，非天然碱基和非天然细胞设计合成及功能研究, 2021.12-2026.11，参与人

科技部，重点研发计划（973计划），若干重要元素的有机化学前沿，2012.1-2016.12，参与人

代表性论文：

(1) Cai Yang, Haitao Zhao, Yang Sun, Cheng Wang, Xinyao Geng, Ruowen Wang, Lumin Tang, Da Han, Jianjun Liu and Weihong Tan. ‘Programmable manipulation of oligonucleotide-albumin interaction for elongated circulation time.’ Nucleic Acids Res.* 2022,50, 3083-3095.

(2) Fei Gao, Jinming Zhou, Yang Sun, Cai Yang, Shiyan Zhang, Ruowen Wang, and Weihong Tan. ‘Programmable Repurposing of Existing Drugs as Pharmaceutical Elements for the Construction of Aptamer-Drug Conjugates’; ACS Appl. Mater. Interfaces 2021, 13, 9457-9463.

(3) Kaiming Chen, Jie Zhou, Zhentao Shao, Jia Liu, Jia Song, RuoWen Wang, Juan Li, and Weihong Tan. ‘Aptamers as Versatile Molecular Tools for Antibody Production Monitoring and Quality Control’; J. Am. Chem. Soc.* 2020, 142, 12079-12086.

(4) Yang Sun, Fei Gao, Cai Yang, Yingying Li, Cheng, Jin, Sitao Xie, Cheng Lv, Ding Ding, Da Han, Juan Li, Ruowen Wang, and Weihong Tan. ‘Construction of Bispecific Aptamer-Drug Conjugate by a Hybrid Chemical and Biological Approach’; Bioconjugate Chem. 2020, 31, 1289-1294.

(5) Razack Abdullah, Sitao Xie, Ruowen Wang, Cheng Jin, Yulin Du, Ting Fu, Juan Li, Jie Tan, Lili Zhang, and Weihong Tan. ‘Artificial Sandwich Base for Monitoring Single-Nucleobase Changes and Charge-Transfer Rates in DNA.’ Anal. Chem. 2019, 91, 2074-2078.

(6) RuoWen Wang, Cheng Jin, Xiaoyan Zhu, Liyi Zhou, Wenjing Xuan, Yuan Liu, Qiaoling Liu, and Weihong Tan. ‘Artificial Base zT as Functional “Element” for Constructing Photoresponsive DNA Nanomolecules’; J. Am. Chem. Soc.* 2017, 139, 9104-9107.

(7) Cheng Jin, Ting Fu, RuoWen Wang*, Hui Liu, Jiamei Zou, Zilong Zhao, Mao Ye, Xiaobing Zhang and Weihong Tan*. ‘Fluorinated molecular beacons as functional DNA nanomolecules for cellular imaging’; Chem. Sci. 2017, 8, 7082-7086.

(8) RuoWen Wang*, Danqing Lu, Huarong Bai, Cheng Jin, Guobei Yan, Mao Ye, Liping Qiu, Rongshan Chang, Cheng Cui, Hao Liangand Weihong Tan*. ‘Using modified aptamers for site specific protein–aptamer conjugations’; Chem. Sci. 2016, 7, 2157-2161.

(9) RuoWen Wang, Chunming Wang, Yang Cao, Zhi Zhu, Chaoyong Yang, Jianzhong Chen, Feng-Ling Qing and Weihong Tan*. ‘Trifluoromethylated Nucleic Acid Analogues Capable of Self-Assembly through Hydrophobic Interactions’; Chem. Sci. 2014, 5, 4076-4081.

(10) RuoWen Wang, Guizhi Zhu, Lei Mei, Yan Xie, Mao Ye, Feng-Ling Qing and Weihong Tan*. ‘Automated and Modular Synthesis of Aptamer-Drug Conjugates for Targeted Drug Delivery’; J. Am. Chem. Soc. 2014, 136, 2731-2734.

(11) Ruo-Wen Wang and Barry Gold*. ‘A Facile Synthetic Approach to 7-Deazaguan-ine Nucleosides via a Boc Protection Strategy’; Org. Lett., 2009, 11, 2465–2468.

(12) Ruo-Wen Wang, Xiao-Long Qiu, Mikael Bols, Fernando Ortega Caballero and Feng-Ling Qing*. ‘Synthesis and Biological Evaluation of Glycosidase Inhibitors:gem-Difluoro-Methylenated Nojirimycin Analogues’; J. Med. Chem. 2006; 49, 2989.

(13) Ruo-Wen Wang, Jun Xu‌, Oscar Lopez‌, Mikael Bols, Feng-Ling Qing*. ‘Difluoromethylenated PolyhydroxylatedPyrrolidines: Facile Synthesis, Crystal Structure and Biological Evaluation’; Future Medicinal Chemistry2009, 1, 991-997.

(14) Ruo-Wen Wang and Feng-Ling Qing*. ‘Highly Stereocontrolled Synthesis of gem-Difluoromethylenated Azasugars: D- and L-1,4,6-Trideoxy-4,4-difluoronojirimycin’; Org. Lett.2005, 7, 2189-2192.

(1) Cai Yang, Haitao Zhao, Yang Sun, Cheng Wang, Xinyao Geng, Ruowen Wang*, Lumin Tang, Da Han, Jianjun Liu* and Weihong Tan*. ‘Programmable manipulation of oligonucleotide-albumin interaction for elongated circulation time.’ Nucleic Acids Res. 2022,50, 3083-3095.

(2) Fei Gao, Jinming Zhou, Yang Sun, Cai Yang, Shiyan Zhang, Ruowen Wang*, and Weihong Tan*. ‘Programmable Repurposing of Existing Drugs as Pharmaceutical Elements for the Construction of Aptamer-Drug Conjugates’; ACS Appl. Mater. Interfaces 2021, 13, 9457-9463.

(3) Kaiming Chen, Jie Zhou, Zhentao Shao, Jia Liu, Jia Song, RuoWen Wang*, Juan Li*, and Weihong Tan*. ‘Aptamers as Versatile Molecular Tools for Antibody Production Monitoring and Quality Control’; J. Am. Chem. Soc. 2020, 142, 12079-12086.

(4) Yang Sun, Fei Gao, Cai Yang, Yingying Li, Cheng, Jin, Sitao Xie, Cheng Lv, Ding Ding, Da Han, Juan Li, Ruowen Wang*, and Weihong Tan*. ‘Construction of Bispecific Aptamer-Drug Conjugate by a Hybrid Chemical and Biological Approach’; Bioconjugate Chem. 2020, 31, 1289-1294.