李星光

特聘研究员，博导，中共党员

籍贯：安徽安庆

Email：lixingguang@ecust.edu.cn

联系电话：15801880116

地址：上海市徐汇区梅陇路130号，实验三楼301室

招生专业

• 有机化学

• 生物与医药

教育与工作经历

2011.09–2017.12华东理工大学，化学与分子工程分学院，理学博士，导师：刘培念教授

2015.09 –2017.09美国加州大学圣塔芭芭拉分校，化学与生物化学系，国家公派联培，导师：张立明教授

2018.03 –2021.09香港科技大学，化学系，博士后研究员，合作导师：孙建伟教授、唐本忠院士

2021.11–至今华东理工大学，化学与分子工程分学院，特聘研究员、博士生导师

研究领域

• 功能有机分子设计及其在肿瘤诊疗中应用

• 生物医用分子/材料设计、合成及应用

• 催化不对称合成及药物活性分子开发

个人荣誉与获奖

• “化学之星”（2023）

• 上海市海外高层次人才（上海千人–领军海外）（2021）

发表论文

迄今在国际主流期刊发表论文35篇。以通讯或第一作者在NatureCatalysis、NatureSynthesis、NatureCommunications(2篇)、Angew. Chem. Int. Ed. (4篇)、Science Advances、Advanced Materials(2篇)、Biomaterials、Small、ACS Catalysis、CCS Chemistry等期刊发表论文29篇，其中影响因子（IF）>10论文14篇。申请发明专利10项，授权2项。

主要成果如下：

1. X. Li*, X.-Z. Wang, B. Shen, Q.-Y. Chen, H. Xiang, P. Yu*, P.-N. Liu*, Organocatalyzed diastereo- and enantioselective synthesis of N–N atropisomeric isoindolinones bearing central chirality, Nature Communications,2025, 16, 1662.

2. X. Li, R. Yan, M. Tan, R. T. K. Kwok, J. Sun, H. Xiang,* X. Ma,* J. W. Y. Lam,* B. Z. Tang,*Facile Access to Piezoelectric Polyamides by Polyamidation of Carboxylic Acids and Ynamides for Potent Tumor Immunotherapy.Angew. Chem.Int. Ed.,2025,64, e202424923.

3. H. Xu, X. Qiao, J. Liang, L. Qiu, L. Xue, Y. Fang, H. Xiang,X. Li,* Y. Chen,* H. Ding,*Organomolecular Ferroelectric Nanocatalyst Augments Tumor Immunotherapy by Inducing Apoptosis and Ferroptosis. Advanced Materials, 2025,37, 2417422.

4. Q.-H. Xu, X.-Y. Yin, Z.-Q. Chen, E.-K. Huang, X. Yao,* X. Li,* P.-N. Liu,* Construction of In Situ Personalized Cancer Vaccines by Bioorthogonal Catalytic Microneedles for Augmented Melanoma Immunotherapy. Small,2025, 21, 2500015.

5. R. Yan, X. Cheng, Y. Song, H. Wang, R. Zhang, Y. Jin,X. Li,* Y. Chen,* H. Xiang,*Cuproptosis Nanoprodrug-Initiated Self-Promoted Cascade Reactions for Postoperative Tumor Therapy.Biomaterials,2025,318, 123176.

6. C.-H. Shu, L.-X. Kang, S.-S. Wang, Y. He, R.-X. Zhang, X. Su, P. Yu, X. Li*, P.-N. Liu*, Hierarchical On-Surface Synthesis of Two-Dimensional Networks via Multipoint S···N and S···H Bonding,CCS Chemistry,2025, 7, 170–179.

7. X. Li*, M.-L. Gao, S.-S. Wang, Y. Hu, D. Hou, P.-N. Liu*, H. Xiang*, Nanoscale covalent organic framework-mediated pyroelectrocatalytic activation of immunogenic cell death for potent immunotherapy,Science Advances,2024,10, eadr5145.

8. X. Li*, J.-X. Guo, J. Zhang, Q.-Y. Chen, Y.-J. He, F. Sha, H. Xiang, P. Yu,* P.-N. Liu*, Asymmetric Dearomatization of Non-Functionalized 1-Naphthols via Copper-Catalyzed Enantioselective [4+1] Spiroannulation, ACS Catalysis,2024, 14, 9244–9253.

9. X. Li*, M.-L. Gao, S.-S. Wang, Y.-L. Li, T.-N. Liu, H. Xiang*, P.-N. Liu,*Engineering an Organic Nanoplatform for Augmented Pyroeletroimmunotherapy, Advanced Materials, 2024,36, 2400756.

10. C. You⁺, X. Li⁺(coauthor), D. Wang, H. Chen, L. Liang, Y. Chen,* Y. Zhao,* H. Xiang,* Self-Assembled Aza-Boron-Dipyrromethene for Ferroptosis-Boosted Sonodynamic Therapy,Angew. Chem.Int. Ed.,2022, 61, e202210174.

11. X. Li, Z. Li, J. Sun*, Quinone methides and indole imine methides as intermediates in enantioselective catalysis, Nature Synthesis, 2022, 1, 426–438.

12. X. Li, M. Duan, P. Yu, K. N. Houk*, J. Sun*, Organocatalytic Enantioselective Dearomatization of Thiophenes by 1,10-Conjugate Addition of Indole Imine Methide,Nature Communications,2021, 12, 4881. (IF: 16.6)

13. X. Li, M. Duan, Z. Deng, Q. Shao, M. Chen, G. Zhu*, K. N. Houk*, J. Sun*, Catalytic Enantioselective Synthesis of Chiral Tetraarylmethane, Nature Catalysis,2020, 3, 1010–1019. (IF: 37.8)

14. X. Li, J. Sun*, "Enantioselective Synthesis of Chiral Allenes: Remote Asymmetric 1,8-Addition of Indole Imine Methide, Angew. Chem. Int. Ed.,2020, 59, 17049–17054. (Hot paper) (IF: 16.6)

15. X. Li, X. Ma, Z. Wang, P.-N. Liu*, L. Zhang*, Bifunctional Phosphine Ligand Enabled Gold-Catalyzed Alkynamide Cycloisomerization: Access to Electron-Rich 2-Aminofurans and Their Diels-Alder Adducts, Angew. Chem. Int. Ed.,2019, 58, 17180–17184. (IF: 16.6)

16. J. Li, L. Wang, P.-N. Liu,X. Li,*Synthesis of oxa-bridged carbocycles via rhodium/Lewis acid catalyzed [3+3] and [4+3] cycloadditions of carbonyl ylides with donor–acceptor strained carbocycles, Org. Chem. Front.,2025,12, 491–496.

17. J.-H. Cui, Q.-Y. Chen, J. Zhang, Y. He,* X. Li,* P.-N. Liu,* Visible light-induced cascade annulation of sulfoxonium ylides withazides for the synthesis of 2-trifluoromethyl indoles,Chem. Commun.,2025, 61, 488–491.

18. J.-H. Cui, M. Tan, J. Zhang,Y. He,*X. Li,*P.-N. Liu,*Highly selective visible-light-induced cascade cyclization of vinyl sulfoxonium ylides with azides: a novel synthetic approach towards trisubstituted furans, Org. Chem. Front.,2025,12, 1905–1910.

19. Y. Jian, Y.-J. He, C. Hu, X. Li,* and P.-N. Liu,* Catalyst-Free [4+1] Annulation of α-Imidoyl Sulfoxonium Ylides and Diazo Compounds Enabling the Modular Synthesis of 2-Indanones and 3(2H)-Furanones. Org. Lett.,2024, 26, 8492−8497.

20. X.-Q. Xie, X. Li,* P.-N. Liu,*Enantioselective synthesis of spiro-N,O-ketals via iridium and Brønsted acid co-catalyzed asymmetric formal [4+2] cycloaddition, Chem. Commun.,2024, 60, 1448–1451.

21. J. Wang, S.-S. Wang, J. Xiao, Y.-J. He, X.-Y. Wu, X. Li,* P.-N. Liu,* Formal (4+2) cycloaddition of azoalkenes with trifluoromethylimidoyl sulfoxonium ylides: synthesis of trifluoromethyl pyridazine derivatives. Chem. Commun.,2023, 59, 12495−12498.

22. J. Wang, Q.-Y. Li, S.-S. Wang, X.-Y. Wu,X. Li,*P.-N. Liu,* Rhodium-Catalyzed 1,4-Aryl Rearrangement of Sulfur Ylide for the Synthesis of 2-Pyridyl Thioethers. Org. Lett., 2023, 25, 703–706.

23. X. Li, J. Sun,* Asymmetric Dearomatization Enabled by Chiral Brønsted Acid Activation of Ynamides. Sci. China: Chem., 2022, 65, 3−4.