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李星光


李星光，教授，博士生导师

国家高层次青年人才（国家优青）、上海海外高层次人才

Email：lixingguang@ecust.edu.cn（报考请联系）

办公地址：上海市徐汇区梅陇路130号华东理工大学实验三楼301室


招生专业

有机化学、化学生物学、生物与医药


欢迎有志于有机合成与生物医用方向、怀揣科研理想、追求卓越的本科生、硕士生、博士生及博士后加入我们！

教育与工作经历

2011.09 – 2017.12 华东理工大学，化学与分子工程学院，

理学博士，导师：刘培念教授

2015.09 – 2017.09 美国加州大学圣塔芭芭拉分校，化学与生物化学系，

国家公派联培，导师：张立明教授

2018.03 – 2021.09 香港科技大学，化学系，

博士后研究员，合作导师：孙建伟教授、唐本忠院士

2021.11 –至今    华东理工大学，化学与分子工程学院，

博士生导师，特聘研究员、副教授、教授


研究方向

  • 功能有机分子设计及其在肿瘤诊疗中应用

  • 生物医用分子/材料设计、合成及应用

  • 催化不对称合成及药物活性分子开发


荣誉与获奖

  • 国家高层次青年人才（国家优青，2025）

  • 东岳药业奖教金-特等奖（2025）

  • 优秀教师奖（2025）

  • “化学之星”（2023）

  • 上海海外高层次人才（上海千人，2021）

  • 优秀博士毕业生（2018）

  • 博士生国家奖学金（2015）

  • 国家公派留学奖学金（2015）


项目与论文

主持国家/省部级等科研项目10余项，包括国家自然科学基金优秀青年基金、面上项目、青年项目，及上海海外高层次人才项目等。在国际主流期刊发表论文42篇。以通讯或第一作者在Nature Catalysis、Nature Synthesis、Nature Communications (2篇)、Science Advances、Angewandte Chemie International Edition (4篇)、Advanced Materials (2篇)、CCS Chemistry等期刊发表论文34篇。申请发明专利10项，授权2项。


代表性成果

  1. J. Guo, Q. Chen, C. Han, X. Wang, W. Xu, W. Yan, H. Xiang*, X. Ma*, G. Huang*, X. Li*, Palladium-catalyzed asymmetric [4+3] cycloaddition of cycloamidines with trimethylenemethanes to access chiral bridged [3.2.2] bicycles. Sci. China Chem.2026, DOI: 10.1007/s11426-025-3300-y. (IF: 9.8)

  2. S. Liu, R. Zhang, Y. Jin, Z. Ming*, X. Li*, H. Xiang*, Biomaterial-mediated reactive oxygen species regulation for cancer immunotherapy: mechanisms and applications. Coord. Chem. Rev.‌2026, 557, 217719. (IF: 25.6)

  3. X. Li*, X. Wang, B. Shen, Q. Chen, H. Xiang, P. Yu*, P. Liu*, Organocatalyzed diastereo- and enantioselective synthesis of N–N atropisomeric isoindolinones bearing central chirality. Nat. Commun.2025, 16, 1662. (IF: 18.1)

  4. X. Li, R. Yan, M. Tan, R. T. K. Kwok, J. Sun, H. Xiang*, X. Ma*, J. W. Y. Lam*, B. Z. Tang*

Facile Access to Piezoelectric Polyamides by Polyamidation of Carboxylic Acids and Ynamides for Potent Tumor Immunotherapy. Angew. Chem. Int. Ed.2025, 64, e202424923.(IF: 17.6)

  1. H. Xu, X. Qiao, J. Liang, L. Qiu, L. Xue, Y. Fang, H. Xiang, X. Li*, Y. Chen*, H. Ding*Organomolecular Ferroelectric Nanocatalyst Augments Tumor Immunotherapy by Inducing Apoptosis and Ferroptosis. Adv. Mater. 2025, 37, 2417422.(IF: 29.1)

  2. C. Shu, L. Kang, S. Wang, Y. He, R. Zhang, X. Su, P. Yu, X. Li*, P. Liu*,Hierarchical On-Surface Synthesis of Two-Dimensional Networks via Multipoint S···N and S···H Bonding.CCS Chem.2025, 7, 170–179. (IF: 9.2)

  3. H. Wang, J. Liang, R. Zhang, Y. Jin, R. Yan, X. Li*, Y. Chen*, H. Xiang*, Multi-Stage Energy Conversion in Covalent Organic Frameworks for Electrogenesis Boosted Immunotherapy. Small, 2025, 21, e04883. (IF: 11.8)

  4. Q. Xu, Yin, Z. Chen, E. Huang, X. Yao*, X. Li*, P. Liu*, Construction of In Situ Personalized Cancer Vaccines by Bioorthogonal Catalytic Microneedles for Augmented Melanoma Immunotherapy. Small, 2025, 21, 2500015. (IF: 11.8)

  5. R. Yan, X. Cheng, Y. Song, H. Wang, R. Zhang, Y. Jin, X. Li*, Y. Chen*, H. Xiang*, Cuproptosis Nanoprodrug-Initiated Self-Promoted Cascade Reactions for Postoperative Tumor Therapy, Biomaterials, 2025, 318, 123176. (IF: 13.6)

  6. X. Li*, M. Gao, S. Wang, Y. Hu, D. Hou, P. Liu*, H. Xiang*, Nanoscale covalent organic framework-mediated pyroelectrocatalytic activation of immunogenic cell death for potent immunotherapy. Sci. Adv. 2024, 10, eadr5145.(IF: 13.9)

  7. X. Li*, M. Gao, S. Wang, Y. Li, T. Liu, H. Xiang*, P. Liu*, Engineering an Organic Nanoplatform for Augmented Pyroeletroimmunotherapy. Adv. Mater.2024, 36, 2400756. (IF: 29.1)

  8. X. Li*, J. Guo, J. Zhang, Q. Chen, Y. He, F. Sha, H. Xiang, P. Yu*, P. Liu*, Asymmetric Dearomatization of Non-Functionalized 1-Naphthols via Copper-Catalyzed Enantioselective [4+1] Spiroannulation, ACS Catal.2024, 14, 9244–9253. (IF: 13.6)

  9. C. You+, X. Li+(coauthor), D. Wang, H. Chen, L. Liang, Y. Chen*, Y. Zhao*, H. Xiang*, Self-Assembled Aza-Boron-Dipyrromethene for Ferroptosis-Boosted Sonodynamic Therapy.Angew. Chem. Int. Ed.2022, 61, e202210174.(IF: 17.6)

  10. X. Li, Z. Li, J. Sun*, Quinone methides and indole imine methides as intermediates in enantioselective catalysis. Nat. Synth. 2022, 1, 426–438.(IF: 22.6)

  11. X. Li, M. Duan, P. Yu, K. N. Houk*, J. Sun*, Organocatalytic Enantioselective Dearomatization of Thiophenes by 1,10-Conjugate Addition of Indole Imine Methide. Nat. Commun.2021, 12, 4881. (IF: 18.3)

  12. X. Li, M. Duan, Z. Deng, Q. Shao, M. Chen, G. Zhu*, K. N. Houk*, J. Sun*, Catalytic Enantioselective Synthesis of Chiral Tetraarylmethane. Nat. Catal.2020, 3, 1010–1019. (IF: 48.3)

  13. X. Li, J. Sun*, Enantioselective Synthesis of Chiral Allenes: Remote Asymmetric 1,8-Addition of Indole Imine Methide. Angew. Chem. Int. Ed.2020, 59, 17049–17054. (Hot paper, IF: 17.6)

  14. X. Li, X. Ma, Z. Wang, P.-N. Liu*, L. Zhang*,Bifunctional Phosphine Ligand Enabled Gold-Catalyzed Alkynamide Cycloisomerization: Access to Electron-Rich 2-Aminofurans and Their Diels-Alder Adducts.Angew. Chem. Int. Ed.2019, 58, 17180–17184.(IF: 17.6)
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