燕宸旭，教授，博士生导师

地址：上海市徐汇区梅陇路130号，华东理工大学，实验三楼435A

邮箱：chenxuyan@ecust.edu.cn

科研/人才项目：

青年科学基金项目B类 [国家优秀青年基金]

上海市青年科技启明星

研究生招收专业：

博士招收专业：应用化学、精细合成化学与分子工程、化学生物学

硕士招收专业：精细合成化学与分子工程、化学生物学

研究领域：

研究聚焦时空分辨生物荧光传感，发展高性能荧光染料与探针，实现从亚细胞、活细胞、组织至活体层面的生物光学成像应用，解析动态生命过程。已发表SCI论文70余篇；申请发明专利19项，授权11项。以第一/通讯作者发表论文33篇，包括Nat. Biomed. Eng. (1篇)、Nat. Aging (1篇)、Nat. Protoc. (1篇)、Nat. Commun. (2篇)、J. Am. Chem. Soc. (2篇)、Angew. Chem. Int. Ed. (6篇)、Chem. Sci. (6篇)、Sci. China Chem. (2篇)、Adv. Funct. Mater. (2篇)、Acc. Mater. Res. (1篇)等。入选青年科学基金项目B类[原国家优秀青年基金]、中国化学会光化学青年新锐奖、Wiley中国高贡献作者、上海市青年科技启明星、上海市超级博士后等。

个人简历：

2009-2013年，华东理工大学，化学与分子工程学院，学士；

2013-2018年，华东理工大学，化学与分子工程学院，博士（导师：朱为宏院士）；

2018-2021年，华东理工大学，生物荧光传感研究方向，博士后（合作导师：田禾院士）。

2021年-至今，华东理工大学，化学与分子工程学院，历任特聘副研究员、副教授、教授。

代表性论文：

1. Dai#; Wei#; Yan*; Ji; Liu; Huang; Liang; Liu; Guo*; Zhu*, Multiplex imaging of amyloid-β plaques dynamics in living brains with quinoline-malononitrile-based probes. Nat. Biomed. Eng.2025, 9, 1632-1644.

2. Yan#; Liu#; Liu; Zheng; Zhao; Lu; Fu; Li; Li; Li; Yao; Zhang; Zhu; Shi; Zhu; Guo*, Fluorescence lifetime clocks quantify senescence and aging. Nat. Aging2025, 5, 2532-2545.

3. Yan; Dai; Yao; Fu; Tian; Zhu; Guo*, Preparation of near-infrared AIEgen-active fluorescent probes for mapping amyloid-β plaques in brain tissues and living mice. Nat. Protoc.2023, 18, 1316-1336.

4. Yao; Chen; Yan*; Gao; Liu; Zhu; Fan; Guo*, Excitation-matchable shortwave infrared quinolinium fluorophores: decoding spatiotemporal interactions with multiplexed bioimaging. J. Am. Chem. Soc.2025, 147, 46953-46965.

5. Yan; Guo; Chi; Fu; Abedi; Liu; Tian; Zhu*, Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents. Nat. Commun.2021, 12, 3869.

6. Yao; Chen; Yan*; Wang; Liu; Zhu; Fan; Guo*, Photo-triggered fluorescence polyelectrolyte nanoassemblies: manipulate and boost singlet oxygen in photodynamic therapy. Angew. Chem. Int. Ed.2025, 64, 202416963.

7. Yan#; Zhu#; Li; Xu; Li; Zhang; Leng; Shao*; Zhu*, Mapping dynamic protein clustering with AIEgen-active chemigenetic probe. Angew. Chem. Int. Ed.2025, 64, 202422996.

8. Yao; Ding; Yan*; Tao; Peng; Liu; Wang; Cohen Stuart; Guo*, Fluorescent probes based on AIEgen-mediated polyelectrolyte assemblies for manipulating intramolecular motion and magnetic relaxivity. Angew. Chem. Int. Ed.2023, 62, 202218983.

9. Fu#; Yao#; Liu; Guo; Yan*; Zhu, Self-adaptive photodynamic therapy for boosting therapeutic efficiency in tumor. Sci. China. Chem.2025, 68, 4497-4506.

10. Yan; Zhu; Yao; Wang; Guo; Zhu*, Engineering near-infrared fluorescent probes based on modulation of molecular excited states. Acc. Mater. Res.2024, 5, 64-75.

11. Liu; Lu; Yan*; Zhao; Yang; Zhang; Zhao; Ge; You; Guo*, Sequential metabolic probes illuminate nuclear DNA for discrimination of cancerous and normal cells. Chem. Sci.2025, 16, 6837-6844.

12. He#; Yao#; Yan*; Yu; Dai; Li; Zhu; Xiao*; Guo*, Spatio-temporally profiling human lung cancer surgery with a FRET‐mediated AIEgen‐active nanoprobe. Adv. Funct. Mater.2025, 35, 2502087.

13. Tao; Yan*; Wu; Li; Li; Xie; Cheng; Xu; Yang; Zhu; Guo*, Uniting dual-modal MRI/chemiluminescence nanotheranostics: spatially and sensitively self‐reporting photodynamic therapy in oral cancer. Adv. Funct. Mater.2023, 33, 202303240.

14. Yan; Xu; Wu; Zhao; Zhao; Tang,; Guo*, Engineering molecular self-assembly of theranostic nanoprobes for dual-modal imaging-guided precise chemotherapy. Sci. China Chem.2021, 64, 2045-2052.

15. Yan; Guo*; Liu; Shi; Tian; Zhu*, A sequence-activated AND logic dual-channel fluorescent probe for tracking programmable drug release. Chem. Sci.2018, 9, 6176-6182.

16. Yan; Guo*; Shen; Chen; Tian; Zhu*, Molecularly precise self-assembly of theranostic nanoprobes within a single-molecular framework for in vivo tracking of tumor-specific chemotherapy. Chem. Sci.2018, 9, 4959-4969.

17. Yan; Zhang; Guo*, Recent progress on molecularly near-infrared fluorescent probes for chemotherapy and phototherapy. Coord. Chem. Rev.2021, 427, 213556.

18. Liu#; Sun#; Dai#; Yan*; Zhang; Guo*, Engineering high-performance dicyanomethylene-4H-pyran fluorophores for biosensing and phototherapy. Coord. Chem. Rev.2024, 503, 215652.

19. Li; Dai; Chen; Li; Chen; Yan*; Guo*, In situ lighting-up near-infrared metabolic probes for superresolution imaging of glycogen. ACS Sens.2025, 10, 2339-2346.

20. Fu#; Yan#; Guo*; Zhang; Zhang*; Tian; Zhu*, Rational design of near-infrared aggregation-induced-emission-active probes: in situ mapping of amyloid-β plaques with ultrasensitivity and high-fidelity. J. Am. Chem. Soc.2019, 141, 3171-3177.

21. Shi#; Yan#; Guo*; Chi; Wei; Liu; Liu*; Tian; Zhu*, De novo strategy with engineering anti-Kasha/Kasha fluorophores enables reliable ratiometric quantification of biomolecules. Nat. Commun.2020, 11, 793.

22. Ma#; Yan#; Guo*; Tan; Niu; Li; Zhu, Spatio-temporally reporting dose-dependent chemotherapy via uniting dual-modal MRI/NIR imaging. Angew. Chem. Int. Ed.2020, 59, 21143-21150.

23. Zhang#; Yan#; Wang; Guo*; Liu; Zhu, A sequential dual-lock strategy for photoactivatable chemiluminescent probes enabling bright duplex optical imaging. Angew. Chem. Int. Ed.2020, 59, 9059-9066.

24. Wu#; Yan#; Li; You; Yu*; Wu; Zheng; Liu; Guo; Tian; Zhu*, Circularly polarized fluorescence resonance energy transfer (C-FRET) for efficient chirality transmission within an intermolecular system. Angew. Chem. Int. Ed.2021, 60, 24549-24557.