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燕宸旭



燕宸旭,博士,副教授,硕士生导师


上海市青年科技启明星(2022)、上海市“超级博士后”(2018

研究聚焦“如何基于强化荧光传感与生理环境耦合作用,精准获取多维度生物学信息”的关键科学问题,创新传感机制、示踪策略、多模式协同方法,从亚细胞、活细胞、组织乃至活体层面突破生物光学成像应用研究瓶颈,解析动态生命过程。已发表SCI论文60余篇,申请中国发明专利17项,已授权7项。以第一/共一/通讯作者发表论文30篇,包括Nat. Biomed. Eng. (1)Nat. Protoc. (1)Nat. Commun. (2)J. Am. Chem. Soc. (1)Angew. Chem. Int. Ed. (6)Chem. Sci. (3)Sci. China Chem. (2)Acc. Mater. Res. (1)Coord. Chem. Rev. (2)等。入选中国化学会光化学青年新锐奖、“Wiley中国高贡献作者”。


研究生招收专业:精细合成化学与分子工程

邮箱:chenxuyan@ecust.edu.cn

ORCIDhttps://orcid.org/0000-0001-7130-769X


个人简历

2009-2013年,华东理工大学,化学与分子工程学院,材料化学,学士;

2013-2018年,华东理工大学,化学与分子工程学院,精细合成化学与分子工程,博士(导师:朱为宏院士、郭志前教授);

2018-2021年,华东理工大学,生物荧光传感研究方向,博士后(合作导师:田禾院士)。

2021-至今,华东理工大学,材料生物学与动态化学前沿科学中心,历任特聘副研究员、副教授。


代表性论著

  1. Dai#; Wei#; Yan*; Ji; Liu; Huang; Liang; Liu; Guo*; Zhu*, Multiplex imaging of amyloid-β plaques dynamics in living brains with quinoline-malononitrile-based probes. Nat. Biomed. Eng.2025, 10.1038/s41551-025-01392-x.

  2. Yan; Dai; Yao; Fu; Tian; Zhu; Guo*, Preparation of near-infrared AIEgen-active fluorescent probes for mapping amyloid-β plaques in brain tissues and living mice. Nat. Protoc.2023, 18, 1316-1336.

  3. Yao; Chen; Yan*; Wang; Liu; Zhu; Fan; Guo*, Photo-triggered fluorescence polyelectrolyte nanoassemblies: manipulate and boost singlet oxygen in photodynamic therapy. Angew. Chem. Int. Ed.2025, 64, 202416963.

  4. Yan#; Zhu#; Li; Xu; Li; Zhang; Leng; Shao*; Zhu*, Mapping dynamic protein clustering with AIEgen-active chemigenetic probe. Angew. Chem. Int. Ed.2025, 202422996.

  5. Yao; Ding; Yan*; Tao; Peng; Liu; Wang; Cohen Stuart; Guo*, Fluorescent probes based on AIEgen-mediated polyelectrolyte assemblies for manipulating intramolecular motion and magnetic relaxivity. Angew. Chem. Int. Ed.2023, 62, 202218983.

  6. Yan; Guo; Chi; Fu; Abedi; Liu; Tian; Zhu*, Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents. Nat. Commun. 2021, 12, 3869.

  7. Fu#; Yao#; Liu; Guo; Yan*; Zhu, Self-adaptive photodynamic therapy for boosting therapeutic efficiency in tumor. Sci. China. Chem.2025, 10.1007/s11426-024-2559-1.

  8. Liu; Lu; Yan*; Zhao; Yang; Zhang; Zhao; Ge; You; Guo*, Sequential metabolic probes illuminate nuclear DNA for discrimination of cancerous and normal cells. Chem. Sci.2025, 16,6837-6844.

  9. Yan; Guo*; Liu; Shi; Tian; Zhu*, A sequence-activated AND logic dual-channel fluorescent probe for tracking programmable drug release. Chem. Sci. 2018, 9, 6176-6182.

  10. Yan; Guo*; Shen; Chen; Tian; Zhu*, Molecularly precise self-assembly of theranostic nanoprobes within a single-molecular framework for in vivo tracking of tumor-specific chemotherapy. Chem. Sci. 2018, 9, 4959-4969.

  11. Shi#; Yan#; Guo*; Chi; Wei; Liu; Liu*; Tian; Zhu*, De novo strategy with engineering anti-Kasha/Kasha fluorophores enables reliable ratiometric quantification of biomolecules. Nat. Commun. 2020, 11, 793.

  12. Fu#; Yan#; Guo*; Zhang; Zhang*; Tian; Zhu*, Rational design of near-infrared aggregation-induced-emission-active probes: in situ mapping of amyloid-β plaques with ultrasensitivity and high-fidelity. J. Am. Chem. Soc.2019, 141, 3171-3177.

  13. He#; Yao#; Yan*; Yu; Dai; Li; Zhu; Xiao*; Guo*, Spatio-temporally profiling human lung cancer surgery with a FRET‐mediated AIEgen‐active nanoprobe. Adv. Funct. Mater.2025, 33, 10.1002/adfm.202502087.

  14. Tao; Yan*; Wu; Li; Li; Xie; Cheng; Xu; Yang; Zhu; Guo*, Uniting dual-modal MRI/chemiluminescence nanotheranostics: spatially and sensitively self‐reporting photodynamic therapy in oral cancer. Adv. Funct. Mater.2023, 33, 202303240.

  15. Yan; Xu; Wu; Zhao; Zhao; Tang,; Guo*, Engineering molecular self-assembly of theranostic nanoprobes for dual-modal imaging-guided precise chemotherapy. Sci. China. Chem.2021, 64, 2045-2052.

  16. Yan; Zhu; Yao; Wang; Guo; Zhu*, Engineering near-infrared fluorescent probes based on modulation of molecular excited states. Acc. Mater. Res.2024, 5, 64-75.

  17. Yan; Zhang; Guo*, Recent progress on molecularly near-infrared fluorescent probes for chemotherapy and phototherapy. Coord. Chem. Rev. 2021, 427, 213556.

  18. Liu#; Sun#; Dai#; Yan*; Zhang; Guo*, Engineering high-performance dicyanomethylene-4H-pyran fluorophores for biosensing and phototherapy. Coord. Chem. Rev.2024, 503, 215652.

  19. Ma#; Yan#; Guo*; Tan; Niu; Li; Zhu, Spatio-temporally reporting dose-dependent chemotherapy via uniting dual-modal MRI/NIR imaging. Angew. Chem. Int. Ed.2020, 59, 21143-21150.

  20. Zhang#; Yan#; Wang; Guo*; Liu; Zhu, A sequential dual-lock strategy for photoactivatable chemiluminescent probes enabling bright duplex optical imaging. Angew. Chem. Int. Ed.2020, 59, 9059-9066.

  21. Wu#; Yan#; Li; You; Yu*; Wu; Zheng; Liu; Guo; Tian; Zhu*, Circularly polarized fluorescence resonance energy transfer (C-FRET) for efficient chirality transmission within an intermolecular system. Angew. Chem. Int. Ed.2021, 60, 24549-24557.


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