刘劲刚
博士生导师、上海市高校特聘教授(东方学者)
第一招生专业：无机化学
第二招生专业：应用化学、材料与化工
联系方式:
Email: liujingang@ecust.edu.cn
办公地点：
徐汇校区实验三楼315室
2000年6月毕业于中山大学，获理学博士学位(Ph.D.)。随后于同济大学化学系任教。2001年8月至2011年8月于日本九州大学先后任日本学术振兴会（JSPS）外国人特别研究员、学术研究员、特任准教授及WPI准教授。2011年9月起华东理工大学校特聘教授。先后入选“浦江人才计划”和“上海市高校特聘教授（东方学者）”。在J. Am. Chem. Soc., Angew Chem. Int. Ed.; ACS Appl. Mater. Interfaces, Chem. Commun., Chem. Eur. J., Coord. Chem. Rev.等国内外期刊发表SCI收录论文八十余篇，论文总引用3900余次。无机化学博士点导师组组长。
研究领域：生物无机化学
研究方向：
（1） 氧分子的活化还原与燃料电池仿生电催化剂。基于仿生催化原理设计不含贵金属的氧分子还原催化剂，作为新型电催化剂最终应用于燃料电池，实现化学能与电能的高效转换。
代表论文:
1. X.-Y. Zhou, C. Xu, P.-P. Guo, W.-L. Sun, P.-J. Wei, and J.-G. Liu,* Axial Ligand Coordination Tuning of the Electrocatalytic Activity of Iron Porphyrin Electrografted onto Carbon Nanotubes for the Oxygen Reduction Reaction, Chem. Eur. J. 2021, 27, 9898-9904 (hot paper).
2. Y.-M. Zhao, P. C. Zhang, C. Xu, X.-Y. Zhou, L.-M. Liao, P.-J. Wei, E. Liu, H. Q. Chen, Q. G. He*, and J.-G. Liu,*, Design and Preparation of Fe-N-5 Catalytic Sites in Single-Atom Catalysts for Enhancing the Oxygen Reduction Reaction in Fuel Cells, ACS Appl. Mater. Interfaces 2020, 12, 17334-17342.
3. Y.-M. Zhao, G.-Q. Yu, F.-F. Wang, P.-J. Wei, and J.-G. Liu,* Bioinspired Transition-Metal Complexes as Electrocatalysts for the Oxygen Reduction Reaction, Chem. Eur. J. 2019, 25, 3762-3739 (Reviews Showcase).
4. Y.-M. Zhao, L.-M. Liao, G.-Q. Yu, P.-J. Wei,* and J.-G. Liu,* B-Doped Fe/N/C Porous Catalyst for High-Performance Oxygen Reduction in Anion-Exchange Membrane Fuel Cells, ChemElectroChem 2019, 6, 1754-1760.
5. F.-F. Wang, Y.-M. Zhao, P.-J. Wei, Q.-L. Zhang and J.-G. Liu,* Efficient electrocatalytic O2 reduction at copper complexes grafted onto polyvinylimidazole coated carbon nanotubes, Chem. Commun. 2017，53, 1514–1517.
6. G.-Q. Yu, P.-J. Wei,* F.-F. Wang, and J.-G. Liu,* Doping Copper Ions into an Fe/N/C Composite Promotes Catalyst Performance for the Oxygen Reduction Reaction, ChemElectroChem 2017, 4, 1509-1515.
7. F.-F. Wang, P.-J. Wei, G.-Q. Yu and J.-G. Liu,* Titanium Dioxide-Grafted Copper Complexes: High-Performance Electrocatalysts for the Oxygen Reduction Reaction in Alkaline Media, Chem. Eur. J. 2016, 22, 382–389 (hot paper).
8. W. Chen, M. Sin, P.-J. Wei, Q.-L. Zhang* and J.-G. Liu,* Synergistic Enhancement of Electrocatalytic Activity toward the Oxygen Reduction Reaction in Alkaline Electrolytes with Pentabasic (Fe, B, N, S, P)-Doped Reduced Graphene Oxide, Chin. J. Chem. 2016, 34, 878–886 (cover paper).
9. Y.-T. Xi, P.-J. Wei, R.-C. Wang and J.-G. Liu,* Bio-inspired multinuclear copper complexes covalently immobilized on reduced graphene oxide as efficient electrocatalysts for the oxygen reduction reaction, Chem. Commun. 2015, 51, 7455–7458.
10. T. Ohta,* J.-G. Liu,* P. Nagaraju, T. Ogura and Y. Naruta,* A cryo-generated ferrous–superoxo porphyrin: EPR, resonance Raman and DFT studies, Chem. Commun. 2015, 51, 12407–12410.
11. P.-J. Wei, G.-Q. Yu, Y. Naruta and J.-G. Liu,* Covalent Grafting of Carbon Nanotubes with a Biomimetic Heme Model Compound To Enhance Oxygen Reduction Reactions, Angew. Chem. Int. Ed. 2014, 53, 6659–6663.
12. J.-G. Liu, Y. Shimizu, T. Ohta and Y. Naruta*, “Formation of an End-On Ferric Peroxo Intermediate upon One-Electron Reduction of a Ferric Superoxo Heme”, J. Am. Chem. Soc. 2010, 132, 3672-3673.
13. J.-G. Liu, T. Ohta, S. Yamaguchi, T. Ogura, S. Sakamoto, Y. Maeda and Y. Naruta*, “Spectroscopic Characterization of a Hydroperoxo–Heme Intermediate: Conversion of a Side-On Peroxo to an End-On Hydroperoxo Complex”, Angew. Chem. Int. Ed. 2009, 48, 9262-9267 (VIP paper). Highlighted by Nature 2010, 463, 168-169; Angew. Chem. Int. Ed. 2010, 49, 2099-2101.
14. J.-G. Liu, Y. Naruta* and F. Tani, “A Functional Model of the Cytochrome c Oxidase Active Site: Unique Conversion of a Heme–μ-peroxo–CuII Intermediate into Heme– superoxo/CuI”, Angew. Chem. Int. Ed. 2005, 44, 1836-1840.
15. J.-G. Liu, Y. Naruta* and F. Tani, “Synthetic Models of the Active Site of Cytochrome c Oxidase: Influence of a Tridentate or Tetradentate Copper Chelate Bearing a His-Tyr Linkage Mimic on Dioxygen Adduct Formation by Heme/Cu Complexes”, Chem. Eur. J. 2007, 13, 6365-6378.
16. J.-G. Liu, Y. Naruta*, F. Tani, T. Chishiro and Y. Tachi, “Formation and spectroscopic characterization of the dioxygen adduct of a heme–Cu complex possessing a cross-linked tyrosine–histidine mimic: modeling the active site of cytochrome c oxidase”, Chem. Commun. 2004, (1), 120-121.
（2）无机纳米药物光控释放。研究无机药物（一氧化氮、一氧化碳、金属钌、铂配合物等）的光控释放及其抗肿瘤特性，构建具有靶向可控投递集诊断与治疗于一体的多功能无机纳米药物体系。
代表论文:
1. Q. Tang, J. Liu, C. B. Wang, L. An, H. L. Zhang, Y. Wang, B. Ren, S. P. Yang*, and J.-G. Liu*, Delivery of carbon monoxide and cysteine protease inhibitor to mitochondria under NIR light enhanced synergistic anticancer efficacy. Nanoscale 2022, DOI:10.1039/D2NR01122K.
2. Q. Tang, Y. T. Yu, H. L. Zhang, Y. Wang, J. Liu, S. P. Yang, and J.-G. Liu*, NIR light-controlled mitochondria-targeted delivery of carbon monoxide combined with histone deacetylase inhibition for synergistic anticancer therapy, J. Inorg. Biochem. 2022, 226, 111656.
3. J. Liu, Q. Tang, H. L. Zhang, Y. Wang, B. Ren, S. P. Yang, and J.-G. Liu*, Targeted Carbon Monoxide Delivery Combined with Chemodynamic, Chemotherapeutic and Photothermal Therapies for Enhanced Antitumor Efficacy, New J. Chem. 2022, 46, 8413-8421.
4. Q. Tang, H. L. Zhang, Y. Wang, J. Liu, S. P. Yang, and J.-G. Liu*, Mitochondria-targeted carbon monoxide delivery combined with singlet oxygen production from a single nanoplatform under 808 nm light irradiation for synergistic anticancer therapy. J. Mater. Chem. B 2021, 9, 4241-4248.
5. H. L. Zhang, Y. T. Yu, Y. Wang, Q. Tang, S. P. Yang, and J.-G. Liu*, Visible light-controlled carbon monoxide delivery combined with the inhibitory activity of histone deacetylases from a manganese complex for an enhanced antitumor therapy, J. Inorg. Biochem. 2021, 216, 111354.
6. Y.-T. Yu, S.-W. Shi, Y. Wang, Q.-L. Zhang*, S.-H. Gao, S.-P. Yang, and J.-G. Liu*, A Ruthenium Nitrosyl-Functionalized Magnetic Nanoplatform with Near-Infrared Light-Controlled Nitric Oxide Delivery and Photothermal Effect for Enhanced Antitumor and Antibacterial Therapy, ACS Appl. Mater. Interfaces 2020, 12, 312-321.
7. S.-W. Shi, Y.-H. Li, Q.-L. Zhang, S.-P. Yang, and J.-G. Liu,* Targeted and NIR light-controlled delivery of nitric oxide combined with a platinum(IV) prodrug for enhanced anticancer therapy, J. Mater. Chem. B 2019, 7, 1867–1874 (Front inside cover).
8. H.-J. Xiang, F.-F. Xue, T. Yi*, H. P. Tham, J.-G. Liu*, and Y. L. Zhao*, Cu2-xS Nanocrystals Cross-Linked with Chlorin e6-Functionalized Polyethylenimine for Synergistic Photodynamic and Photothermal Therapy of Cancer, ACS Appl. Mater. Interfaces 2018, 10, 16344−16351.
9. Y.-H. Li, M. Guo, S.-W. Shi, Q.-L. Zhang, S.-P. Yang, and J.-G. Liu,* Ruthenium-Nitrosyl-Functionalized Nanoplatform for the Targeting of Liver Cancer Cells and NIR-Light Controlled Delivery of Nitric Oxide Combined with Photothermal Therapy, J. Mater. Chem. B 2017, 5, 7831–7838.
10. M. Guo, H.-J. Xiang, Y. Wang, Q.-L. Zhang,* L. An, S.-P. Yang, Y. Ma, Y. Wang and J.-G. Liu,* Ruthenium nitrosyl functionalized graphene quantum dots as an efficient nanoplatform for NIR-light-controlled and mitochondria-targeted delivery of nitric oxide combined with photothermal therapy, Chem. Commun. 2017, 53, 3253–3256.
11. H.-J. Xiang, H. P. Tham, M. D. Nguyen, S. Z. F. Phua, W. Q. Lim, J.-G. Liu* and Y. L. Zhao,* An aza-BODIPY based near-infrared fluorescent probe for sensitive discrimination of cysteine/homocysteine and glutathione in living cells, Chem. Commun. 2017, 53, 5220-5223.
12. H.-J. Xiang, H. Chen, H. P. Tham, S. Z. F. Phua, J.-G. Liu*, and Y. Zhao*, Cyclometalated Iridium(III)-Complex-Based Micelles for Glutathione-Responsive Targeted Chemotherapy and Photodynamic Therapy, ACS Appl. Mater. Interfaces 2017, 9, 27553−27562.
13. H.-J. Xiang, M. Guo, and J.-G. Liu,* Transition-Metal Nitrosyls for Photocontrolled Nitric Oxide Delivery, Eur. J. Inorg. Chem. 2017, 1586–1595 (review).
14. H.-J. Xiang, Q. D., L. An, M. Guo, S.-P. Yang and J.-G. Liu,* Tumor cell specific and lysosome-targeted delivery of nitric oxide for enhanced photodynamic therapy triggered by 808 nm near-infrared light, Chem. Commun. 2016, 52, 148–151.
15. H.-J. Xiang, M. Guo, L. An, S.-P. Yang, Q.-L. Zhang* and J.-G. Liu,* A multifunctional nanoplatform for lysosome targeted delivery of nitric oxide and photothermal therapy under 808 nm near-infrared light, J. Mater. Chem. B 2016, 4, 4667–4674.
16. Q. Deng, H.-J. Xiang, W.-W. Tang, L. An, S.-P. Yang, Q.-L. Zhang and J.-G. Liu,* Ruthenium Nitrosyl Grafted Carbon Dots as a Fluorescence-Trackable Nanoplatform for Visible Light-Controlled Nitric Oxide Release and Targeted Intracellular Delivery, J. Inorg. Biochem. 2016, 165, 152–158.
17. H.-J. Xiang, L. An, W.-W. Tang, S.-P. Yang* and J.-G. Liu,* Photo-controlled targeted intracellular delivery of both nitric oxide and singlet oxygen using a fluorescence-trackable ruthenium nitrosyl functional nanoplatform, Chem. Commun. 2015, 51, 2555–2558.
18. X.-D. Yang, H.-J. Xiang, L. An, S.-P. Yang and J.-G. Liu,* Targeted delivery of photoactive diazido PtIV complexes conjugated with fluorescent carbon dots, New J. Chem. 2015, 39, 800–804.
(3) 二氧化碳的光催化转换与光催化产氢。通过有机-无机复合光催化剂将CO2光催化转换成可利用的化工原料，阐明CO2光催化还原的过程和机理，实现太阳能的储存和转移。
代表论文:
1. X. Zhou, S.-C. Cui*, and J.-G. Liu*, Three-dimensional graphene oxide cross-linked by benzidine as an efficient metal-free photocatalyst for hydrogen evolution, RSC Adv. 2020, 10, 14725–14732.
2. C.-X. Tian, S.-C. Cui*, X.-Y. Liu, and J.-G. Liu*, A hybrid composite of rhenium complexes covalently grafted on reduced graphene oxide/hydrogenated TiO2 as an efficient catalyst for CO2 reduction under visible light, Res. Chem. Intermediat. 2019, 46, 1-13.
3. W.-D. Wei, X.-Y. Liu, S.-C. Cui,* and J.-G. Liu,* Loading of Co3O4 onto Pt-modified Nitrogen-doped TiO2 Nanocomposites Promotes Photocatalytic Hydrogen Production, RSC Adv. 2017, 7, 25650–25656.
4. L. Liu, and J.-G. Liu,* “Encyclopedia of Physical Organic Chemistry”, 6 Volume Sets, Vol. 6, Chapter 70, Artificial Photosynthesis, pp3813–3884. Z. Wang, U. Wille, and E. Juaristi, Eds., Wiley, 2017.
5. S.-C. Cui, X.-Z. Sun, and J.-G. Liu,* Photo-reduction of CO2 Using a Rhenium Complex Covalently Supported on a Graphene/TiO2 Composite, ChemSusChem 2016, 13, 1698–1703.
6. X.-Y. Liu, W.-D. Wei, S.-C. Cui,* and J.-G. Liu,* A Heterojunction Cu2O/N–TiO2 Photocatalyst for Highly Efficient Visible Light-Driven Hydrogen Production, Catal. Lett. 2016, 146, 1655–1662.
7. P. Sun, L. Liu, S.-C. Cui, and J.-G. Liu,* Synthesis, Characterization of Ce-doped TiO2 Nanotubes with High Visible Light Photocatalytic Activity, Catal. Lett. 2014, 144, 2107–2113.