张伟安
教授，博士生导师
联系地址：徐汇校区实验六楼205室
Email: wazhang@ecust.edu.cn
Tel: 021-64253033
Web:https://www.x-mol.com/groups/weian
个人简介：
2003年博士毕业于中国科技大学高分子科学系；2004年为上海交通大学高分子科学系讲师；2007年-至今，为华东理工大学化学与分子工程学院副教授，教授。期间，受洪堡基金会资助在德国Bayreuth大学进行访问研究，洪堡学者；以及欧盟第七框架(PF7)资助在英国利兹大学进行访问研究，玛丽居里学者。
主要从事功能性高分子材料的构建和应用研究，尤其生物医用高分子材料，特种高分子材料制备技术等，在高分子学科相关杂志上以通讯/第一作者发表SCI论文110余篇和撰写英文专著两章节，其中包括Prog. Polym. Sci., Adv. Mater.和Angew. Chem. Int. Ed.等杂志，论文引用3000余次。在项目方面，以项目负责人主持了多项项目，其中包括两项人才项目和四项中国国家自然科学基金面上项目等。
研究方向：
Ø 高分子合成方法学（光引发可控自由基聚合等）；
Ø 含有光敏性基元（如卟啉等）特定结构高分子的构建、组装及其应用（尤其在抗癌治疗中的应用，如诊断、成像和治疗等）；
Ø 生物医用高分子材料（尤其可供组织修复的高分子材料）的构建和应用；
Ø 高分子材料特种制备技术（3D打印成型技术、聚合物反应加工技术、聚氨酯及改性材料等）。
招生专业和毕业学生去向：
目前课题组主要在应用化学，材料科学与工程和制药工程专业招生。毕业学生几乎全部就职于上海，包括高校（上海交大和华东理工等），大型国企（中石化上海分公司，上海烟草集团和上海造币厂等）或跨国公司（如：德国瓦克聚合物公司和日本立邦公司）等。欢迎加盟本课题组攻读硕士、博士学位以及从事博士后研究工作！
近五年发表的主要通讯作者论文
2020
1. Tian, J.; Huang, B. X.; Nawaz, M. H.; Zhang, W. A.*, Recent advances of multi-dimensional porphyrin-based functional materials in photodynamic therapy. Coordination Chemistry Reviews2020, 420, 213410.
2. Liu, Z. Y.; Cao, T. Y.; Xue, Y. D.; Li, M.; Wu, M. S.; Engle, J. W.; He, Q. J.; Cai, W. B.; Lan, M. B.; Zhang, W. A.*, Self-amplified Photodynamic Therapy through 1O2-mediated In Situ Internalization of Photosensitizers from a Ppa-bearing Block Copolymer. Angewandte Chemie-International Edition2020, 59 (9), 3711-3717.
3. Xie, L.; Tian, J.; Ouyang, Y.; Guo, X.; Zhang, W. A.*; Apfel, U.-P.; Zhang, W.; Cao, R.*, Water-Soluble Polymers with Appending Porphyrins as Bioinspired Catalysts for the Hydrogen Evolution Reaction. Angewandte Chemie-International Edition2020, DOI: 10.1002/anie.202003836.
4. Jiang, D. W.; Cheng, L.; Xue, Y. D.; Chen, C.; Wang, C.; Yang, G. L.; Xu, A.*; Yang, Y. J*; Gao, Y.; Zhang, W. A.*, Modulation of the lifespan of C. elegans by the controlled release of nitric oxide. Chemical Science2020,11 (33), 8785-8792.
5. Wang, C. C.; Zhao, P.; Yang, G. L.; Chen, X.; Jiang, Y.; Jiang, X.; Wu, Y.; Liu, Y.; Zhang, W. A.*; Bu, W. B.*, Reconstructing the intracellular pH microenvironment for enhancing photodynamic therapy. Materials Horizons2020, 7 (4), 1180-1185.
6. Huang, B. X.; Wang, P.; Ouyang, Y. J.; Pang, R.; Liu, S.; Hong, C.; Ma, S.; Gao, Y.; Tian, J.*; Zhang, W. A.*, Pillar 5 arene-Based Switched Supramolecular Photosensitizer for Self-Amplified and pH-Activated Photodynamic Therapy. ACS Applied Materials & Interfaces2020, DOI:10.1021/acsami.0c10372.
7. Zhu, Y. C.; Chen, C.; Yang, G. L.; Wu, Q.; Tian, J.; Hao, E. H.; Cao, H. L.; Gao, Y.; Zhang, W. A.*, Inhibiting Radiative Transition Mediated Multifunctional Polymeric Nanoplatforms for High-efficient Tumor Phototherapeutics. ACS Applied Materials & Interfaces2020, DOI:10.1021/acsami.0c12756.
8. Tian, J.; Xia, L.; Wu, J.; Huang, B. X.; Cao, H. L.; Zhang, W. A.*, Linear Alternating Supramolecular Photosensitizer for Enhanced Photodynamic Therapy. ACS Applied Materials & Interfaces2020,12 (29), 32352-32359.
9. Chen, M. J.; Zhang, Y. H.; Zhang, W. A.*; Li, J.*, Polyhedral Oligomeric Silsesquioxane-Incorporated Gelatin Hydrogel Promotes Angiogenesis during Vascularized Bone Regeneration. ACS Applied Materials & Interfaces2020, 12 (20), 22410-22425.
10. Wang, C. C.; Zhao, P.; Jiang, D. W.; Yang, G. L.; Xue, Y. D.; Tang, Z.; Zhang, M.; Wang, H.; Jiang, X.; Wu, Y.; Liu, Y.; Zhang, W. A.*; Bu, W. B.*, In Situ Catalytic Reaction for Solving the Aggregation of Hydrophobic Photosensitizers in Tumor. ACS Applied Materials & Interfaces2020, 12 (5), 5624-5632.
11. Tian, J.; Xiao, C.; Huang, B. X.; Wang, C.; Zhang, W. A.*, Janus macromolecular brushes for synergistic cascade-amplified photodynamic therapy and enhanced chemotherapy. Acta Biomaterialia 2020, 101, 495-506.
12. Xia, L.; Wu, J.; Huang, B. X.; Gao, Y.; Tian, J.*; Zhang, W. A.*, Enhanced photodynamic therapy through supramolecular photosensitizers with an adamantyl-functionalized porphyrin and a cyclodextrin dimer. Chemical Communications2020, DOI:10.1039/d0cc03574b.
13. Liu, Z.; Wu, M.; Xue, Y. D.; Chen, C.; Wurm, F. R.*; Lan, M.; Zhang, W. A.*, Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy. Chemical Communications2020,56 (16), 2415-2418.
14. Zhu, Y. C.; Chen, C.; Wu, Q.; Yang, G. L.; Liu, Z.; Hao, E.; Cao, H. L.; Gao, Y.; Zhang, W. A.*, Single-wavelength phototheranostics for colon cancerviathe thiolytic reaction. Nanoscale2020,12 (22), 12165-12171.
15. Zhang, Y. H.; Chen, M. J.; Dai, Z. B; Cao, H. L.; Li, J.*; Zhang, W. A.*, Sustained protein therapeutics enabled by self-healing nanocomposite hydrogels for non-invasive bone regeneration. Biomaterials Science 2020, 8 (2), 682-693.
16. Zhou, Y.; Zhang, Y. H.; Dai, Z.; Jiang, F.; Tian, J.; Zhang, W. A.*, A super-stretchable, self-healing and injectable supramolecular hydrogel constructed by a host-guest crosslinker. Biomaterials Science2020, 12(8), 3359-3369.
17. Li, J. P.; Xue, Y. D.; Tian, J.; Liu, Z. Y.; Zhuang, A.; Gu, P.; Zhou, H.; Zhang, W. A.*; Fan, X.*, Fluorinated-functionalized hyaluronic acid nanoparticles for enhanced photodynamic therapy of ocular choroidal melanoma by ameliorating hypoxia. Carbohydrate Polymers 2020, 237, 116119.
18. Cao, H. L.; Zhong, S.; Wang, Q.; Chen, C.*; Tian, J.; Zhang, W. A.*, Enhanced photodynamic therapy based on an amphiphilic branched copolymer with pendant vinyl groups for simultaneous GSH depletion and Ce6 release. Journal of Materials Chemistry B2020,8 (3), 478-483.
19. Wang, W.; Zhong, S.; Wang, G.; Cao, H. L.*; Gao, Y.; Zhang, W. A.*, Photo-controlled RAFT polymerization mediated by organic/inorganic hybrid photoredox catalysts: enhanced catalytic efficiency. Polymer Chemistry2020,11 (18), 3188-3194.
20. Xiang, B. W.; Xue, Y. D.; Liu, Z. Y.; Tian, J.; Frey, H.*; Gao, Y.; Zhang, W. A.*, Water-soluble hyperbranched polyglycerol photosensitizer for enhanced photodynamic therapy. Polymer Chemistry 2020,11 (23), 3913-3921.
2019
21. Tian, J.; Zhang, W. A.*, Synthesis, self-assembly and applications of functional polymers based on porphyrins. Progress in Polymer Science2019, 95, 65-117.
22. Tang, Z.; Jiang, F.; Zhang, Y. H.; Zhang, Y.; Yuan, Y.; Huang, X.; Wang, Y.; Zhang, D.; Ni, N.; Liu, F.; Luo, M.; Fan, X.*; Zhang, W. A.*; Gu, P.*, 85-S-Mussel-inspired injectable hydrogel and its counterpart for actuating proliferation and neuronal differentiation of retinal progenitor cells. Biomaterials2019, 194, 57-72.
23. Yang, G. L.; Tian, J.; Chen, C.; Jiang, D. W.; Xue, Y. D.; Wang, C.; Gao, Y.; Zhang, W. A.*, An oxygen self-sufficient NIR-responsive nanosystem for enhanced PDT and chemotherapy against hypoxic tumors. Chemical Science2019, 10 (22), 5766-5772.
24. Cao, H. L.; Wang, G.; Xue, Y. D.; Yang, G. L.; Tian, J.; Liu, F.; Zhang, W. A.*, Far-Red Light-Induced Reversible Addition-Fragmentation Chain Transfer Polymerization Using a Man-Made Bacteriochlorin. ACS Macro Letters2019, 8 (5), 616-622.
25. Yang, G. L.; Chen, C.; Zhu, Y. C.; Liu, Z. Y.; Xue, Y. D.; Zhong, S.; Wang, C.; Gao, Y.; Zhang, W. A.*, GSH-Activatable NIR Nanoplatform with Mitochondria Targeting for Enhancing Tumor-Specific Therapy. ACS Applied Materials & Interfaces2019, 11 (48), 44961-44969.
26. Jiang, D. W.; Chen, C.; Xue, Y. D.; Cao, H. L.; Wang, C.; Yang, G. L.; Gao, Y.; Wang, P.; Zhang, W. A.*, NIR-triggered OFF/ON Photodynamic Therapy through a UCST Block Copolymer. ACS Applied Materials & Interfaces2019, 11(40), 37121-37129.
27. Zhong, S.; Chen, C.; Yang, G. L.; Zhu, Y. C.; Cao, H. L.*; Xu, B.; Luo, Y.; Gao, Y.; Zhang, W. A.*, Acid-Triggered Nanoexpansion Polymeric Micelles for Enhanced Photodynamic Therapy. ACS Applied Materials & Interfaces2019, 11 (37), 33697-33705.
28. Xue, Y. D.; Li, J.; Yang, G. L.; Liu, Z. Y.; Zhou, H.*; Zhang, W. A.*, Multistep Consolidated Phototherapy Mediated by a NIR-Activated Photosensitizer. ACS Applied Materials & Interfaces2019, 11 (37), 33628-33636.
29. Chen, C.; Guo, K.; Zhu, Y. C.; Wang, F.; Zhang, W. A.*; Qi, H. M.*, Construction of Layered B3N3-Doped Graphene Sheets from an Acetylenic Compound Containing B3N3 by a Semisynthetic Strategy. ACS Applied Materials & Interfaces2019, 11 (36), 33245-33253.
30. Liu, Z. Y.; Xue, Y. D.; Wu, M. S.; Yang, G. L.; Lan, M. B.; Zhang, W. A.*, Sensitization of hypoxic tumor to photodynamic therapy via oxygen self-supply of fluorinated photosensitizers.Biomacromolecules2019, 20 (12), 4563-4573.
31. Wang, C.; Huang, B. X.; Yang, G. L.; Ouyang, Y. J.; Tian, J.*; Zhang, W. A.*, NIR-Triggered Multifunctional and Degradable Nanoplatform Based on an ROS-Sensitive Block Copolymer for Imaging-Guided Chemo-Phototherapy. Biomacromolecules2019, 20 (11), 4218-4229.
32. Huang, B. X.; Tian, J.*; Jiang, D. W.; Gao, Y.; Zhang, W. A.*, NIR-Activated OFF/ON Photodynamic Therapy by a Hybrid Nanoplatform with Upper Critical Solution Temperature Block Copolymers and Gold Nanorods. Biomacromolecules2019, 20 (10), 3873-3883.
33. Xue, Y. D.; Tian, J.; Liu, Z. Y.; Chen, J.; Wu, M.; Shen, Y.; Zhang, W. A.*, A Redox Stimulation-Activated Amphiphile for Enhanced Photodynamic Therapy. Biomacromolecules2019, 20 (7), 2796-2808.
34. Tian, J.; Huang, B. X.; Li, H.; Cao, H. L.; Zhang, W. A.*, NIR-Activated Polymeric Nanoplatform with Upper Critical Solution Temperature for Image-Guided Synergistic Photothermal Therapy and Chemotherapy. Biomacromolecules2019, 20 (6), 2338-2349.
35. Chen, C.; Tang, W.; Jiang, D. W.; Yang, G. L.; Wang, X.; Zhou, L.; Zhang, W. A.*; Wang, P.*, Hyaluronic acid conjugated polydopamine functionalized mesoporous silica nanoparticles for synergistic targeted chemo-photothermal therapy. Nanoscale2019, 11 (22), 11012-11024.
36. Ji, T.; Xia, L.; Zheng, W.*; Yin, G.-Q.; Yue, T.; Li, X.; Zhang, W. A.*; Zhao, X. L.*; Yang, H. B., Porphyrin-functionalized coordination star polymers and their potential applications in photodynamic therapy. Polymer Chemistry2019, 10 (45), 6116-6121.
37. Tian, J.; Zhang, W. A.*, Construction and Applications of Well-defined Porphyrin-containing Polymer. Acta Polymerica Sinica2019, 7, 653-670.
38. Chen, M. J.; Zhang, Y. H.; Xie, Q.; Zhang, W. A.*; Pan, X. W.; Gu, P.; Zhou, H.; Gao, Y.; Walther, A.*; Fan, X.*, Long-Term Bone Regeneration Enabled by a Polyhedral Oligomeric Silsesquioxane (POSS)-Enhanced Biodegradable Hydrogel. ACS Biomaterials Science & Engineering2019, 5 (9), 4612-4623.
39. Zhang, Y. H.; Chen, M. J.; Tian, J.; Gu, P.; Cao, H. L.; Fan, X.*; Zhang, W. A.*, In situ bone regeneration enabled by a biodegradable hybrid double-network hydrogel. Biomaterials Science2019, 7 (8), 3266-3276.
40. Jiang, F.; Tang, Z.; Zhang, Y. H.; Ju, Y.; Gao, H.; Sun, N.; Liu, F.; Gu, P.*; Zhang, W. A.*, Enhanced proliferation and differentiation of retinal progenitor cells through a self-healing injectable hydrogel. Biomaterials Science2019, 7 (6), 2335-2347.
41. Li, H.; Huang, W.; Mo, Q.; Liu, B.; Shen, D.; Zhang, W. A.*; Zheng, Z. G.*, Stable soft cubic superstructure enabled by hydrogen-bond complex functionalized polymer/liquid crystal system. Journal of Materials Chemistry C 2019, 7 (13), 3952-3957.
42. Wu, J.; Xia, L.; Liu, Z. Y.; Xu, Z.*; Cao, H. L.*; Zhang, W. A.*, Fabrication of a Dual-Stimuli-Responsive Supramolecular Micelle from a Pillar 5 arene-Based Supramolecular Diblock Copolymer for Photodynamic Therapy. Macromolecular Rapid Communications2019, 40 (18), 1900240.
43. Tian, J.; Huang, B. X.; Zhang, W. A.*, Precisely Self-assembly and Controlled Catalysis of Thermoresponsive Core-Satellite Multicomponent Hybrid Nanoparticles. Langmuir2019, 35 (1), 266-275.
44. Xue, Y. D.; Tian, J.*; Xu, L.; Liu, Z. Y.; Shen, Y. J.; Zhang, W. A.*, Ultrasensitive redox-responsive porphyrin-based polymeric nanoparticles for enhanced photodynamic therapy. European Polymer Journal2019, 110, 344-354.
45. Tian, J.; Xiao, C.; Huang, B. X.; Jiang, X.; Cao, H. L.; Liu , F.; Zhang, W. A.*, Combating Multidrug Resistance through an NIR-Triggered Cyanine-Containing Amphiphilic Block Copolymer. ACS Applied Bio Materials2019, 2 (5), 1862-1874.
2018
46. Zhou, K.; Bisoyi, H. K.; Jin, J. Q.; Yuan, C. L.; Liu, Z.; Shen, D.; Lu, Y. Q.; Zheng, Z. G.*; Zhang, W. A.*; Li, Q.*, Light-Driven Reversible Transformation between Self-Organized Simple Cubic Lattice and Helical Superstructure Enabled by a Molecular Switch Functionalized Nanocage. Advanced Materials2018, 30 (26), 1800237.
47. Jin, J. Q.; Zhu, Y. C.; Zhang, Z. H.; Zhang, W. A.*, Enhancing the Efficacy of Photodynamic Therapy through a Porphyrin/POSS Alternating Copolymer. Angewandte Chemie International Edition2018, 57 (50), 16354-16358.
48. Wu, J.; Tian, J.; Rui, L. L.; Zhang, W. A.*, Enhancing the efficacy of photodynamic therapy (PDT) via water-soluble pillar[5]arene-based supramolecular complexes. Chemical Communications2018, 54 (55), 7629-7632.
49. Jin, J.; Tang, M.; Zhang, Z. H.; Zhou, K.; Gao, Y.; Zheng, Z. G.*; Zhang, W. A.*, Synthesis of POSS-functionalized liquid crystalline block copolymers via RAFT polymerization for stabilizing blue phase helical soft superstructures. Polymer Chemistry2018, 9 (16), 2101-2108.
50. Zhang, Y. H.; Pan, X. W.; Shi, Z.; Cai, H. B.*; Gao, Y.; Zhang, W. A.*, Sustained release of stem cell factor in a double network hydrogel for ex vivo culture of cord blood-derived CD34+ cells. Cell Proliferation2018, 51 (2), e12407.
2017
51. Tian, J.; Xu, L.; Xue, Y. D.; Jiang, X. Z.; Zhang, W. A.*, Enhancing Photochemical Internalization of DOX through a Porphyrin-based Amphiphilic Block Copolymer. Biomacromolecules2017, 18 (12), 3992-4001.
52. Rui, L. L.; Xue, Y. D.; Wang, Y.; Gao, Y.; Zhang, W. A.*, Mitochondria-targeting supramolecular photosensitizer based on pillar 5 arene for photodynamic therapy. Chemical Communications2017, 53 (21), 3126-3129.
53. Wang, C. C.; Liu, L. C.; Cao, H. L.; Zhang, W. A.*, Intracellular GSH-activated galactoside photosensitizers for targeted photodynamic therapy and chemotherapy. Biomaterials Science 2017, 5 (2), 274-284.
54. Zhang, P. C.; Zhang, Z. H.; Jiang, X.; Rui, L. L.; Gao, Y.; Zhang, W. A.*, Unimolecular micelles from POSS-based star-shaped block copolymers for photodynamic therapy. Polymer2017, 118, 268-279.
55. Pan, X. W.; Sun, Q.; Zhang, Y. H.; Cai, H. B.*; Gao, Y.; Shen, Y.; Zhang, W. A.*, Biomimetic Macroporous PCL Scaffolds for Ex Vivo Expansion of Cord Blood-Derived CD34(+) Cells with Feeder Cells Support. Macromolecular Bioscience2017, 17 (8), 1700054.
2016
56. Zhang, Z. H.; Xue, Y. D.; Zhang, P. C.; Muller, A. H. E.; Zhang, W. A.*, Hollow Polymeric Capsules from POSS-Based Block Copolymer for Photodynamic Therapy. Macromolecules2016, 49 (22), 8440-8448.
57. Rui, L. L.; Liu, L. C.; Wang, Y.; Gao, Y.; Zhang, W. A.*, Orthogonal Approach to Construct Cell-Like Vesicles via Pillar 5 arene-Based Amphiphilic Supramolecular Polymers. ACS Macro Letters 2016, 5 (1), 112-117.
58. Pan, H.; Wang, S. F.; Xue, Y. D.; Cao, H. L.; Zhang, W. A.*, Light-controllable toxicity recovery from selenium-based amphiphiles. Chemical Communications2016, 52 (99), 14208-14211.
59. Pan, X. W.; Sun, Q.; Cai, H. B.*; Gao, Y.*; Tan, W. S.; Zhang, W. A.*, Encapsulated feeder cells within alginate beads for ex vivo expansion of cord blood-derived CD34(+) cells. Biomaterials Science2016, 4 (10), 1441-1453.
60. Chen, Y.; Rui, L. L.; Liu, L. C.; Zhang, W. A.*, Redox-responsive supramolecular amphiphiles based on a pillar 5 arene for enhanced photodynamic therapy. Polymer Chemistry2016, 7 (19), 3268-3276.
61. Zhang, Z. H.; Zhang, P.; Wang, Y.; Zhang, W. A.*, Recent advances in organic-inorganic well-defined hybrid polymers using controlled living radical polymerization techniques. Polymer Chemistry2016, 7 (24), 3950-3976.
62. Rui, L. L.; Cao, H. L.*; Xue, Y. D.; Liu, L. C.; Xu, L.; Gao, Y.*; Zhang, W. A.*, Functional organic nanoparticles for photodynamic therapy. Chinese Chemical Letters 2016, 27 (8), 1412-1420.
63. Zhou, Q.; Xu, L.; Liu, F.; Zhang, W. A.*, Construction of reduction-responsive photosensitizers based on amphiphilic block copolymers and their application for photodynamic therapy. Polymer2016, 97, 323-334.
2015
64. Liu, F.*; Zhang, Y.; Xu, L.; Zhang, W. A.*, Morphology-Controlled Self-Assembly of an Organic/Inorganic Hybrid Porphyrin Derivative Containing Polyhedral Oligomeric Silsesquioxane (POSS). Chemistry-A European Journal2015, 21 (14), 5540-5547.
65. Liu, F.; Ma, Y.; Xu, L.; Liu, L. C.; Zhang, W. A.*, Redox-responsive supramolecular amphiphiles constructed via host-guest interactions for photodynamic therapy. Biomaterials Science 2015, 3 (8), 1218-1227.
66. Xu, L.; Zhang, W.; Cai, H. B.; Liu, F.*; Wang, Y.; Gao, Y.; Zhang, W. A.*, Photocontrollable release and enhancement of photodynamic therapy based on host-guest supramolecular amphiphiles. Journal of Materials Chemistry B2015, 3 (37), 7417-7426.
67. Xu, L.; Liu, L. C.; Liu, F.; Li, W.*; Chen, R.; Gao, Y.; Zhang, W. A.*, Photodynamic therapy of oligoethylene glycol dendronized reduction-sensitive porphyrins. Journal of Materials Chemistry B2015, 3 (15), 3062-3071.
68. Xu, L.; Liu, L. C.; Liu, F.*; Cai, H. B.; Zhang, W. A.*, Porphyrin-containing amphiphilic block copolymers for photodynamic therapy. Polymer Chemistry2015, 6 (15), 2945-2954.
69. Wu, B.; Xu, L.; Wang, S. F.; Wang, Y.; Zhang, W. A.*, PEGylated colorimetric and turn-on fluorescent sensor based on BODIPY for Hg(II) detection in water. Polymer Chemistry2015, 6 (23), 4279-4289.
70. Wang, S. F.; Wu, B.; Liu, F.; Gao, Y.; Zhang, W. A.*, Well-defined alternating copolymer based on a salicylaldimine Schiff base for highly sensitive zinc(II) detection and pH sensing in aqueous solution. Polymer Chemistry2015, 6 (7), 1127-1136.
71. Liu, L. C.; Rui, L. L.; Gao, Y.; Zhang, W. A.*, Self-assembly and disassembly of a redox-responsive ferrocene-containing amphiphilic block copolymer for controlled release. Polymer Chemistry2015, 6 (10), 1817-1829.