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赵春常


赵春常 男，教授，博士生导师。

1994-2001年就读于天津大学，并分别获得本科和硕士学位；2001-2004年就读于中科院理化技术研究所，并获得博士学位，师从佟振合院士、吴骊珠院士；2005年1月至2008年7月于美国罗彻斯特大学从事博士后研究；2008年9月起，华东理工大学精细化工研究所担任副教授、教授。

研究兴趣主要围绕国家健康领域的重大需求，创制新型分子探针并探讨其在重大疾病的快速、高效、精准诊疗等方面的应用，以期为医学和生命科学研究提供科学和技术支撑。研究涉及到有机合成化学、高分子化学、超分子化学、光化学和光物理、材料化学、药物化学、化学生物学等领域。

以通讯联系人或第一作者在J. Am. Chem. Soc.,Angew. Chem. Int. Ed.,Nano Lett., Chem. Sci., Biomaterials, Anal. Chem., Chem. Commun.等国际著名刊物发表SCI文章60余篇。

主持国家自然科学基金面上项目（5项），国家自然科学基金青年基金（1项），参与国家自然科学基金重大项目。主持教育部留学回国人员启动基金、中央高校基本科研业务费等。项目“功能染料稳定性强化原理与应用基础研究”荣获2019年国家自然科学奖二等奖（排名第五）。

联系方式：上海市梅陇路130号华东理工大学实验13楼117。

E-mail： zhaocchang@ecust.edu.cn，Tel：13788995376

代表性文章

  1. Tianli Zhu, Ning Ren, Xia Liu, Yan Dong, Rongchen Wang, Jinzhu, Gao, Jie Sun, Ying Zhu, Lihua Wang, Chunhai Fan, He Tian, Jiang Li,* Chunchang Zhao,* “Probing the Intracellular Dynamics of Nitric Oxide and Hydrogen Sulfide Using an Activatable NIR II Fluorescence Reporter”, Angew. Chem. Int. Ed.2021, 10.1002/anie.202015650.

  2. Rongchen Wang, Xianfeng Gu, Qizhao Li, Jie Gao, Ben Shi, Ge Xu, Tianli Zhu, He Tian, Chunchang Zhao,* “Aggregation Enhanced Responsiveness of Rationally Designed Probes to Hydrogen Sulfide for Targeted Cancer Imaging”, J. Am. Chem. Soc. 2020, 142, 15084-15090.

  3. Ge Xu, Wei Guo, Xianfeng Gu, Zhijun Wang, Rongchen Wang, Tianli Zhu, He Tian, Chunchang Zhao,* “Hydrogen Sulfide-Specific and NIR-Light-Controllable Synergistic Activation of Fluorescent Theranostic Prodrugs for Imaging-Guided Chemo-Photothermal Cancer Therapy”, CCS Chem.2020, 2, 527-538.

  4. Ben Shi, Ning Ren, Luyan Gu, Ge Xu, Rongchen Wang, Tianli Zhu, Ying Zhu,* Chunhai Fan,* Chunchang Zhao,* He Tian, “Theranostic Nanoplatform with Hydrogen Sulfide Activatable NIR Responsiveness for Imaging-Guided On-Demand Drug Release”, Angew. Chem. Int. Ed.2019, 58, 16826-16830.

  5. Rongchen Wang, Jian Chen, Jie Gao, Ji-An Chen, Ge Xu, Tianli Zhu, Xianfeng Gu, Zhiqian Guo, Wei-Hong Zhu and Chunchang Zhao,* “A Molecular Design Strategy toward Enzyme-Activated Probes with Near-Infrared I and II Fluorescence for Targeted Cancer Imaging”, Chem. Sci., 2019, 10, 7222-7227.

  6. Rongchen Wang, Kaikai Dong, Ge Xu, Ben Shi, Tianli Zhu, Ping Shi,* Zhiqian Guo, Wei-Hong Zhu, Chunchang Zhao,* “Activatable Near-Infrared Emission-Guided On-Demand Administration of Photodynamic Anticancer Therapy with a Theranostic Nanoprobe”, Chem. Sci., 2019, 10, 2785–2790.

  7. Ge Xu, Qinglong Yan, Xiaoguang Lv, Ying Zhu,* Kai Xin, Ben Shi, Rongchen Wang, Jian Chen, Wei Gao, Ping Shi, Chunhai Fan,* Chunchang Zhao,* He Tian, “Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near-Infrared Window Emission”, Angew. Chem. Int. Ed.2018, 57, 3626-3630.

  8. Ben Shi, Qinglong Yan, Jie Tang, Kai Xin, Jichao Zhang, Ying Zhu,* Ge Xu, Rongchen Wang, Jian Chen, Wei Gao, Tianli Zhu, Jiye Shi, Chunhai Fan,* Chunchang Zhao,* He Tian, “Hydrogen Sulfide-Activatable Second Near-Infrared Fluorescent Nanoassemblies for Targeted Photothermal Cancer Therapy”, Nano Lett.2018, 18, 6411–6416.

  9. Feiyi Wang, Ge Xu, Xianfeng Gu, Zhijun Wang, Zhiqiang Wang, Ben Shi, Cuifen Lu, Xueqing Gong, Chunchang Zhao,* “Realizing highly chemoselective detection of H2S in vitro and in vivo with fluorescent probes inside core-shell silica nanoparticles”, Biomaterials2018,159, 82-90.

  10. Yingchao Liu, Jie Tan, Yi Zhang, Jianfeng Zhuang, Mingxu Ge, Ben Shi, Jiao Li, Ge Xu, Shangchen Xu,* Chunhai Fan,* Chunchang Zhao,* “Visualizing glioma margins by real-time tracking of γ-glutamyltranspeptidase activity”, Biomaterials2018, 173, 1-10.

  11. Ben Shi, Xianfeng Gu, Qiang Fei, Chunchang Zhao,* “Photoacoustic Probes for Real-Time Tracking of Endogenous H2S in Living Mice”, Chem. Sci., 2017, 8, 2150-2155.

  12. Ben Shi, Xianfeng Gu, Zhijun Wang, Ge Xu, Qiang Fei, Jie Tang, Chunchang Zhao,* “Fine Regulation of Porous Architectures of Core−Shell Silica Nanocomposites Offers Robust Nanoprobes with Accelerated Responsiveness”, ACS Appl. Mater. Interfaces 2017, 9, 35588-35596.

  13. Chunchang Zhao,* Xiuli Zhang, Kaibin Li, Shaojia Zhu, Zhiqian Guo, Lili Zhang, Feiyi Wang, Qiang Fei, Sihang Luo, Ping Shi,* He Tian, Wei-Hong Zhu,* “Förster Resonance Energy Transfer Switchable Self-Assembled Micellar Nanoprobe: Ratiometric Fluorescent Trapping of Endogenous H2S Generation via Fluvastatin-Stimulated Upregulation”, J. Am. Chem. Soc. 2015, 137, 8490-8498.

  14. Feiyi Wang, Ying Zhu, Li Zhou, Liang Pan, Zhifen Cui, Qiang Fei, Sihang Luo, Dun Pan, Qing Huang, Rui Wang, Chunchang Zhao,* He Tian, Chunhai Fan,* “Fluorescent In Situ Targeting Probes for Rapid Imaging of Ovarian-Cancer Specific γ-Glutamyltranspeptidase”, Angew. Chem. Int. Ed.2015, 54, 7349-7353.

  15. Feiyi Wang, Li Zhou, Chunchang Zhao,* Rui Wang, Qiang Fei, Sihang Luo, Zhiqian Guo, He Tian, Weihong Zhu,* “A dual-response BODIPY-based fluorescent probe for the discrimination of glutathione from cysteine and homocystein”, Chem. Sci.2015, 6, 2584-2589.




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