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朱麟勇

朱麟勇

华东理工大学,化学与分子工程学院,特聘教授

国家杰出青年基金获得者(2014,化学)

上海市“东方学者”特聘教授

受教育经历:

•1995/07 – 2000/06,中科院感光化学研究所,博士学位

导师:王尔鉴研究员


•1991/09 – 1995/06,北京师范大学,化学系,学士学位

研究工作经历:


•2007/10 至今,华东理工大学,教授


•2006/03 – 2007/09,美国加州大学圣地亚哥分校,博士后


•2003/11 – 2006/02,美国华盛顿州立大学,博士后


•2000/07 – 2003/10,中科院理化技术研究所,助理研究员


研究方向:

1.光响应生物医用材料(智能水凝胶,药物控释)


2.化学与生物荧光传感



工作简介:

朱麟勇教授的研究一直聚焦于光化学与生物医用材料,特别是,在“光化学方法构建生物医用材料”方向的研究逐步形成特色。他提出光触发反应耦合,实施非自由基光调控交联的创新机制,由此推动医用光敏生物胶领先技术的临床转化;提出人工合成生色团的荧光蛋白的构建,创制高特异、高亮度、从蓝光至近红外光发射任意调控的系列荧光探针,成功应用于蛋白的荧光成像、定量以及相互作用等实时动态研究;提出 “可控光剪切” 的新机制,创制高差异性光控药物释放体系,达到高度选择性杀死肿瘤细胞的目的;提出借助双光子等上转换手段,实施近红外光诱导“光剪切”化学反应,实现组织深穿透、“适时”、“适地”、“适量”地精确控制肿瘤药物释放。这些成果开拓了光化学方法解决生命与医学中重要问题的新方向,充分体现“光”的可视与可控的独特优势。以上研究工作先后在J. Am. Chem. Soc.、Angew. Chem.Int. Ed.、Adv. Mater.等学术期刊上发表,获得了国际同行的认同和高度评价,所建立的方法被多个国际知名研究组跟踪、沿用。


代表性成果:

1.Coumarin Photocages Modified with an Electron-Rich Styryl Moiety at the 3-Position: Long Wavelength Excitation, Rapid Photolysis and Photobleaching, Qiuning Lin+, Lipeng Yang+, Zhiqiang Wang, Yujie Hua, Dasheng Zhang, Bingkun Bao, Chunyan Bao, Xueqing Gong, Linyong Zhu*,Angew. Chem. Int. Ed., 10.1002/ange.201800713.


2.Photogenerated Aldehydes for Protein Patterns on Hydrogels and Guidance of Cell Behavior, Zunzheng Ming, Jinyan Fan, Chunyan Bao*, Yuan Xue, Qiuning Lin, Linyong Zhu*,Adv. Funct. Mater.,2018, 1706918.


3.Micropatterned Protein for Cell Adhesion through Phototriggered Charge Change in a Polyvinylpyrrolidone Hydrogel, Zunzheng Ming, Xing Ruan, Chunyan Bao*, Qiuning Lin, Yi Yang, Linyong Zhu*,Adv. Funct. Mater., 2017, 27, 1606258.


4.Tissue-Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction,Yunlong Yang+, Jieyuan Zhang+, Zhenzhen Liu, Qiuning Lin*, Xiaolin Liu, Chunyan Bao, Yang Wang*, Linyong Zhu*, Adv. Mater., 2016, 28, 2724-2730.


5.Sequential Control over Thiol Click Chemistry by a Reversibly Photoactivated Thiol Mechanism of Spirothiopyran, Zhenzhen Liu, Tao Liu, Qiuning Lin*, Chunyan Bao, Linyong Zhu*, Angew Chem Int. Ed., 2015, 54, 174-178.


6.Building Biomedical Materials using Photochemical Bond Cleavage, Chunyan Bao, Linyong Zhu*, Qiuning Lin, He Tian, Adv. Mater., 2015, 27, 1647-1662.


7.Spatiotemporally Controllable and Cytocompatible Approach Builds 3D Cell Culture Matrix by Photo-Uncaged-Thiol Michael Addition Reaction, Zhenzhen Liu, Qiuning Lin, Yun Sun, Tao Liu, Chunyan Bao, Fuyou Li, Linyong Zhu*, Adv. Mater., 2014, 26, 3912-3917.


8.Near-Infrared Photoregulated Drug Release in Living Tumor Tissue via Yolk-Shell Upconversion Nanocages, Linzhi Zhao, Juanjuan Peng, Qi Huang, Chunyan Li, Min Chen, Yun Sun, Qiuning Lin, Linyong Zhu*, Fuyou Li*, Adv. Funct. Mater., 2014, 24, 363-371.


9.Highly Discriminating Photorelease of Anticancer Drugs Based on Tumor-Hypoxia Activatable Phototriggers Conjugated Chitosan Nanoparticles, Qiuning Lin, Chunyan Bao, Yunlong Yang, Qiannan Liang, Dasheng Zhang, Shuiyu Cheng, Linyong Zhu*, Adv. Mater., 2013, 24, 1981-1986.


10.Target-Activated Coumarin Phototriggers Specifically Switch on Fluorescence and Photocleavage upon Bonding to Thiol-Bearing Protein, Qiuning Lin, Chunyan Bao, Shuiyu Cheng, Yunlong Yang, Wei Ji, Linyong Zhu*, J. Am. Chem. Soc.,2012, 134, 5052-5055.


11.Anticancer Drug Release from a Mesoporous Silica Based Nanophotocage Regulated by Either a One- or Two-Photon Process,Qiuning Lin, Qi Huang, Chunyan Li, Chunyan Bao*, Zhenzhen Liu, Fuyou Li, Linyong Zhu*, J. Am. Chem. Soc., 2010, 132, 10645-10647.


12.Reversibly Photoswitchable Dual-Color Fluorescence Nanoparticles as a New Tool for Cell Imaging, Linyong Zhu, Wuwei Wu, Mingqiang Zhu, Jason J. Han, James K. Hurst*, Alexander D. Q. Li*,J. Am. Chem. Soc., 2007, 129, 3524-3526.


13.Photoregulated Transmembrane Charge Separation by Linked Spiropyran- Anthraquinone Molecules,Linyong Zhu, Rafail F. Khairutdinov, James K. Hurst*, J. Am. Chem. Soc., 2006, 128, 825-835.


14.Light-Controlled Molecular Switches Modulate Nanocrystal Fluorescence,Linyong Zhu, Mingqiang Zhu, James K. Hurst*, Alexander D. Q. Li*, J. Am. Chem. Soc.,2005, 127, 8968-8970.


网页发布时间: 2014-11-19 11:04