徐首红 女 博士
教授，博士生导师 xushouhong@ecust.edu.cn
1991年大学本科毕业于华东化工学院无机材料系，获学士学位；1995年赴日本名古屋市立大学药学部留学，2001年获博士学位，2002年至2004年作为日本学术振兴会(JSPS)，2004年回国至今在华东理工大学化学与分子工程学院，从事生物高分子、蛋白质等大分子的纳微米颗粒自组装结构、界面性质及其药物输送等方面的研究工作。
研究领域：
生物大分子，聚电解质，两亲性大分子的有序排列、自组装和界面行为，及其在生物医药领域的应用。
研究方向：
1）设计、合成智能型、功能化两亲性的大分子，研究其界面行为和自组装结构，获得多重(温度、pH、光)刺激响应型控释材料，评价作为催化剂、药物载体的应用价值。
2）无机/有机核壳结构纳微颗粒的组装设计，研发新型、新功能的具有生物活性的组织工程修补材料和药物载体。
主持科研项目：
2011.1-2013.12：软骨组织修复用无机/有机杂化核壳结构微凝胶，国家自然科学基金面上项目，项目负责人；
2013.1-2016.12：合成糖脂在磷脂单分子、双分子层膜中的界面行为研究—DNA载体的设计及制备，国家自然科学基金面上项目，项目负责人；
2014.1-2017.12： 多相反应过程中的表界面结构和相际传递现象研究，国家自然科学基金“多相反应过程中的介尺度机制及调控”重大研究计划培育项目, 重要参与人；
2018.1-2021.12：智能大分子在生物膜环境中的相应行为及其对膜功能的调控机制，64万，国家自然科学基金面上项目，项目负责人 徐首红。
2021.1 – 2024.12：（22078087）用于核酸、蛋白质等生物大分子胞内运输的准固态纳米体系的构建，国家自然科学基金面上项目，项目负责人。
近期发表论文：
(1) Jun Xu, Yehong Liu, Gaoyang Li, Mingxia Peng, Shouhong Xu*, Honglai Liu, A reduction-triggered nanocarrier based on host-guest interaction between pillar[5]arene derivative and viologen on MSN for intracellular delivery, Journal of Drug Delivery Science and Technology, 2022, 68, 103055.
(2) Jun Xu, Gaoyang Li, Yuhua Zhang, Yuhan Kang, Shouhong Xu* and Honglai Liu，A dual-responsive drug delivery system based on mesoporous silica nanoparticles covered with zipper-type peptide for intracellular transport/release. Colliod surface A, 2021, 631, 127672.
(3) Bin Lei, Minjia Sun, Miaoxin Chen, Shouhong Xu*, Honglai Liu, pH and temperature double-switch hybrid micelles for controllable drug release, Langmuir, 37 (50)：14628-14637
(4) Bin Lei1, Miaoxin Chen1, Yizhou Wang1, Junqi Zhang*, Shouhong Xu*, and Honglai Liu, Double security drug delivery system DDS constructed by multi-responsive (pH/redox/US) microgel, Colliod surface B, 2020, 193: 111022
(5) Yizhou Wang, Bin Lei, Jun Xu, Minjia Sun, Shouhong Xu* and Honglai Liu, A pH/reduction dual-sensitive copolymer inserted in liposomal bilayer acts as a protective “umbrella”, Colliod surface A, 2020, 602: 125128.
(6) Yizhou Wang, Bin Lei, Minjia Sun, Xia Han,* Shouhong Xu, and Honglai Liu, Accurate Targeting and Controllable Release of Hybrid Liposome Containing a Stretchable Copolymer, Macromol. Chem. Phys. 2020, 221(7): 1900536(1 of 9)
(7) Mengya Li, Sijia Wang, Jun Xu, Shouhong Xu*, Honglai Liu，pH/redox-controlled interaction between lipid membranes and peptide derivative with a “Helmet”, J. Phys. Chem. B, 2019, 123, 31: 6784-6791.
(8) Sijia Wang, Mengya Li, Shouhong Xu*, Honglai Liu, Two/three-dimensional interfacial behaviors of a novel peptide as a selective destroyer of biomembrane, Colloids and Surfaces A, 2019, 574: 62-68.
(9) Yinxing Shen, Mengya Li, Tianqi Liu, Jing Liu, Youhua Xie, Junqi Zhang*, Shouhong Xu* and Honglai Liu, A dual-functional HER2 aptamer-conjugated, pH-activated mesoporous silica nanocarrier-based drug delivery system provides in vitro synergistic cytotoxicity in HER2-positive breast cancer cells, International Journal of Nanomedicine. 2019, 14: 4029-4044.
(10) Xueru Zhang, Bin Lei, Yizhou Wang, Shouhong Xu*, Honglai Liu, Dual-sensitive on-off Switch in Liposome Bilayer for Controllable Drug Release, Langmuir, 2019 , 35: 5213−5220.
(11) Xiangye Li, Danyang Liu, Yizhou Wang, Shouhong Xu* and Honglai Liu,
Water Dispersive Upconversion Nanoparticles for Intelligent Drug Delivery System, Colloids and Surfaces A, 2018, 555: 55–62.
(12) Sijia Wang, Tong Wang, Junqi Zhang, Shouhong Xu*, Honglai Liu, Disruption of tumor cells using a pH-activated and thermo-sensitive antitumor lipopeptide containing a leucine zipper structure, Langmuir, 2018, 34: 8818-8827.
(13) Nengwei Shen, Bin Lei, Yizhou Wang, Shouhong Xu*, Honglai Liu*, Redox/Ultrasound Dual Stimuli-Responsive Nanogel for Precisely Controllable Drug Release, New Journal of Chemistry, 2018, 42: 9472-9481.
(14) Yinxing Shen, Junqi Zhang, Weiju Hao, Tong Wang, Jing Liu, Youhua Xie*, Shouhong Xu* and Honglai Liu, Copolymer Micelles function as pH-responsive Nanocarriers to Enhance the cytotoxicity of a HER2 aptamer in HER2-Positive Breast Cancer Cells, International Journal of Nanomedicine. 2018, 13: 537-553.
(15) Weiju Hao, Danyang Liu, Yizhou Wang, Xia Han, Shouhong Xu*, Honglai Liu, Dual-Stimuli Responsive Nanoparticles (UCNP-CD@APP) Assembled by Host-Guest Interaction for Drug Delivery, Colloids and Surfaces A:Physicochemical and Engineering Aspects. Colloids and Surfaces A, 2018, 537: 446-451.
授权发明专利：
专利号：201110147125.3，徐首红，蔺肖肖，李成亮，翟春涛，刘洪来：温敏性核壳型囊泡控释药物载体、其制备方法及应用
专利号：201310046158.8，徐首红，李相晔，刘欢，李成亮，刘洪来：TiO2-HA核壳结构防晒颗粒、其制备方法及应用
专利号：201410820848.9，徐首红，李炜，王斯佳，刘洪来：温度敏感性脂肽、含该脂肽的脂质体及其应用
专利号：201410263844.5，徐首红，陈汝婷，刘洪来，段朝辉：含偶氮苯基的糖苷及其制备方法与应用
专利号：201410573140.8，徐首红，郝伟举，薛涛，尚亚卓，刘洪来：pH敏感的Bola型嵌段物及含该嵌段物的脂质体控释药物载体