燕宸旭，博士，副教授，硕士生导师

上海市青年科技启明星（2022）、上海市“超级博士后”（2018）

研究聚焦“如何基于强化荧光传感与生理环境耦合作用，精准获取多维度生物学信息”的关键科学问题，创新传感机制、示踪策略、多模式协同方法，从亚细胞、活细胞、组织乃至活体层面突破生物光学成像应用研究瓶颈，解析动态生命过程。已发表SCI论文60余篇，申请中国发明专利17项，已授权7项。以第一/共一/通讯作者发表论文30篇，包括Nat. Biomed. Eng. (1篇)、Nat. Protoc. (1篇)、Nat. Commun. (2篇)、J. Am. Chem. Soc. (1篇)、Angew. Chem. Int. Ed. (6篇)、Chem. Sci. (3篇)、Sci. China Chem. (2篇)、Acc. Mater. Res. (1篇)、Coord. Chem. Rev. (2篇)等。入选中国化学会光化学青年新锐奖、“Wiley中国高贡献作者”。

研究生招收专业：精细合成化学与分子工程

邮箱：chenxuyan@ecust.edu.cn

ORCID：https://orcid.org/0000-0001-7130-769X

个人简历

2009-2013年，华东理工大学，化学与分子工程学院，材料化学，学士；

2013-2018年，华东理工大学，化学与分子工程学院，精细合成化学与分子工程，博士（导师：朱为宏院士、郭志前教授）；

2018-2021年，华东理工大学，生物荧光传感研究方向，博士后（合作导师：田禾院士）。

2021年-至今，华东理工大学，材料生物学与动态化学前沿科学中心，历任特聘副研究员、副教授。

代表性论著

1. Dai#; Wei#; Yan*; Ji; Liu; Huang; Liang; Liu; Guo*; Zhu*, Multiplex imaging of amyloid-β plaques dynamics in living brains with quinoline-malononitrile-based probes. Nat. Biomed. Eng.2025, 10.1038/s41551-025-01392-x.

2. Yan; Dai; Yao; Fu; Tian; Zhu; Guo*, Preparation of near-infrared AIEgen-active fluorescent probes for mapping amyloid-β plaques in brain tissues and living mice. Nat. Protoc.2023, 18, 1316-1336.

3. Yao; Chen; Yan*; Wang; Liu; Zhu; Fan; Guo*, Photo-triggered fluorescence polyelectrolyte nanoassemblies: manipulate and boost singlet oxygen in photodynamic therapy. Angew. Chem. Int. Ed.2025, 64, 202416963.

4. Yan#; Zhu#; Li; Xu; Li; Zhang; Leng; Shao*; Zhu*, Mapping dynamic protein clustering with AIEgen-active chemigenetic probe. Angew. Chem. Int. Ed.2025, 202422996.

5. Yao; Ding; Yan*; Tao; Peng; Liu; Wang; Cohen Stuart; Guo*, Fluorescent probes based on AIEgen-mediated polyelectrolyte assemblies for manipulating intramolecular motion and magnetic relaxivity. Angew. Chem. Int. Ed.2023, 62, 202218983.

6. Yan; Guo; Chi; Fu; Abedi; Liu; Tian; Zhu*, Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents. Nat. Commun. 2021, 12, 3869.

7. Fu#; Yao#; Liu; Guo; Yan*; Zhu, Self-adaptive photodynamic therapy for boosting therapeutic efficiency in tumor. Sci. China. Chem.2025, 10.1007/s11426-024-2559-1.

8. Liu; Lu; Yan*; Zhao; Yang; Zhang; Zhao; Ge; You; Guo*, Sequential metabolic probes illuminate nuclear DNA for discrimination of cancerous and normal cells. Chem. Sci.2025, 16,6837-6844.

9. Yan; Guo*; Liu; Shi; Tian; Zhu*, A sequence-activated AND logic dual-channel fluorescent probe for tracking programmable drug release. Chem. Sci. 2018, 9, 6176-6182.

10. Yan; Guo*; Shen; Chen; Tian; Zhu*, Molecularly precise self-assembly of theranostic nanoprobes within a single-molecular framework for in vivo tracking of tumor-specific chemotherapy. Chem. Sci. 2018, 9, 4959-4969.

11. Shi#; Yan#; Guo*; Chi; Wei; Liu; Liu*; Tian; Zhu*, De novo strategy with engineering anti-Kasha/Kasha fluorophores enables reliable ratiometric quantification of biomolecules. Nat. Commun. 2020, 11, 793.

12. Fu#; Yan#; Guo*; Zhang; Zhang*; Tian; Zhu*, Rational design of near-infrared aggregation-induced-emission-active probes: in situ mapping of amyloid-β plaques with ultrasensitivity and high-fidelity. J. Am. Chem. Soc.2019, 141, 3171-3177.

13. He#; Yao#; Yan*; Yu; Dai; Li; Zhu; Xiao*; Guo*, Spatio-temporally profiling human lung cancer surgery with a FRET‐mediated AIEgen‐active nanoprobe. Adv. Funct. Mater.2025, 33, 10.1002/adfm.202502087.

14. Tao; Yan*; Wu; Li; Li; Xie; Cheng; Xu; Yang; Zhu; Guo*, Uniting dual-modal MRI/chemiluminescence nanotheranostics: spatially and sensitively self‐reporting photodynamic therapy in oral cancer. Adv. Funct. Mater.2023, 33, 202303240.

15. Yan; Xu; Wu; Zhao; Zhao; Tang,; Guo*, Engineering molecular self-assembly of theranostic nanoprobes for dual-modal imaging-guided precise chemotherapy. Sci. China. Chem.2021, 64, 2045-2052.

16. Yan; Zhu; Yao; Wang; Guo; Zhu*, Engineering near-infrared fluorescent probes based on modulation of molecular excited states. Acc. Mater. Res.2024, 5, 64-75.

17. Yan; Zhang; Guo*, Recent progress on molecularly near-infrared fluorescent probes for chemotherapy and phototherapy. Coord. Chem. Rev. 2021, 427, 213556.

18. Liu#; Sun#; Dai#; Yan*; Zhang; Guo*, Engineering high-performance dicyanomethylene-4H-pyran fluorophores for biosensing and phototherapy. Coord. Chem. Rev.2024, 503, 215652.

19. Ma#; Yan#; Guo*; Tan; Niu; Li; Zhu, Spatio-temporally reporting dose-dependent chemotherapy via uniting dual-modal MRI/NIR imaging. Angew. Chem. Int. Ed.2020, 59, 21143-21150.

20. Zhang#; Yan#; Wang; Guo*; Liu; Zhu, A sequential dual-lock strategy for photoactivatable chemiluminescent probes enabling bright duplex optical imaging. Angew. Chem. Int. Ed.2020, 59, 9059-9066.

21. Wu#; Yan#; Li; You; Yu*; Wu; Zheng; Liu; Guo; Tian; Zhu*, Circularly polarized fluorescence resonance energy transfer (C-FRET) for efficient chirality transmission within an intermolecular system. Angew. Chem. Int. Ed.2021, 60, 24549-24557.