报告题目: Functionalization and targeted delivery of Pt(IV) anticancer prodrugs
报 告 人: 朱光宇 博士 (香港城市大学)
报告时间: 2017-06-16 （周五）  15:00
报告地点: 徐汇校区研究生楼104室

报告简介：

   Despite the broad clinical applications of platinum-based anticancer drugs including cisplatin, their side-effects and resistance issues have encouraged researchers to look for novel metal-based anticancer complexes. Non-traditional platinum compounds have been extensively studied and they hold the promise to be further developed as the next-generation platinum drugs. On the other hand, using nanomaterials to deliver cisplatin specifically into cancer cells has proven to be promising to increase the anticancer efficacy of cisplatin and has been a hot topic in the recent years. In this presentation, I will summarize the recent progress in my laboratory in 1) the design, synthesis, and biological evaluation of dual-targeting non-traditional platinum anticancer agents and 2) the application of low-cytotoxic and effective drug delivery systems to deliver platinum compounds together with other small-molecules specifically into tumors to increase their antitumor activity. Examples of platinum constructs that promote the activation of p53 pathway will be given.