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陈宜峰


陈宜峰 教授，博士生导师

办公地址：实验三楼416室；联系电话：021-64252422

Email:yifengchen@ecust.edu.cn

课题组主页：https://www.x-mol.com/groups/YifengChen

OCID: 0000-0003-3239-6209

研究生招生专业：有机化学；生物与医药


学习及工作经历:

07/2017-:  教授，华东理工大学化学与分子工程学院

02/2014-06/2017:  博士后, 美国耶鲁大学化学系，导师: Timothy R. Newhouse教授

02/2013-01/2014:  博士后, 美国麻省理工学院化学系，导师: Stephen L. Buchwald教授

07/2012-01/2013:  研究助理, 中国科学院上海有机化学研究所，导师: 刘元红研究员

09/2007-06/2012:  博士，中国科学院上海有机化学研究所，导师: 刘元红研究员

09/2003-07/2007:  学士，苏州大学化学化工学院化学专业，导师: 邹建平教授


研究方向：有机合成化学（过渡金属催化合成方法学）

1）不对称催化：设计新型手性配体，聚焦多层次手性中心精准构筑

2）羰基化反应：发展温和条件下丰产过渡金属催化的羰基化反应

3）分子编辑：开发新方法、新技术实现非张力环状分子骨架重组


科研项目：

  1. 海外高层次人才计划（青年项目）

  2. 国家自然科学基金面上项目

  3. 国家自然科学基金青年项目

  4. 上海市科委-青年科技启明星项目

  5. 上海市科委“原创探索”项目基金


代表性著作：

  1. Wu, X.; Xia, H.; Gao, C.; Luan, B.; Wu, L.; Zhang, C.; Yang, D.; Hou, L.; Liu, N.; Xia, T.; Li, H.; Qu, J.; Chen, Y.* Modular -Tertiary Amino Ester Synthesis Through Cobalt-Catalyzed Asymmetric aza-Barbier Reaction. Nat. Chem.2023, doi: 10.1038//s41557-023-01378-9.

  2. Weng, Y.+; Zhang, Y.+; Turlik, A.+; Wu, X.+; Li, H.; Fei, F.; Yao, Y.; Wang, C.; Guo, Z.; Qu, J. Houk, K. N.*; Chen, Y.* Nickel-Catalysed Regio- and Stereoselective Acylzincation of Unsaturated Hydrocarbons with Organozincs and CO. Nat. Synth.2023, 2, 261.

  3. Wu, X.; Wang, C.; Liu, N.; Qu, J.; Chen, Y.* Nickel-Catalyzed Acylzincation of Allenes with Organozincs and CO. Nat. Commun.2023, 14, 6960.

  4. He, F.; Hou, L.; Wu, X.; Ding, H.; Qu, J.; Chen, Y.* Enantioselective Synthesis of α-Alkenylated γ-Lactam Enabled by Ni-Catalyzed 1,4-Arycarbamoylation of 1,3-Dienes. CCS Chem.2023,5, 341.

  5. Wang, C.; Wu, X.; Li, H.; Qu, J.; Chen, Y.* Carbonylative Cross-Coupling Reaction of Allylic Alcohols and Organoalanes with 1 atm CO Enabled by Nickel Catalysis. Angew. Chem. Int. Ed. 2022, 61, e202210484.

  6. Wu, X.+; Turlik, A.+; Luan, B.; He, F.; Qu, J.; Houk, K. N.*; Chen, Y.*Nickel-Catalyzed Enantioselective Reductive Alkyl-Carbamoylation of Internal Alkenes. Angew. Chem. Int. Ed. 2022, 61, e202207536.

  7. Xi, Y.; Huang, W.; Wang, C.; Ding, H.; Xia, T.; Wu, L.; Fang, K.; Qu, J.; Chen, Y.* Catalytic Asymmetric Diarylation of Internal Acyclic Styrenes and Enamides. J. Am. Chem. Soc.2022, 144, 8389.

  8. Wu, X.; Luan, B.; Zhao, W.; He, F.; Wu, X.-Y.; Qu, J.; Chen, Y.* Catalytic Desymmetric Dicarbofunctionalization of Unactivated Alkenes. Angew. Chem. Int. Ed. 2022, 61, e202111598.

  9. Zhang, C.; Wu, X.; Xia, T.; Qu, J. Chen, Y.* Ni-catalyzed Carbamoylation of Unactivated Alkenes for Stereoselective Construction of Six-Membered Lactams. Nat. Commun.2022, 13, 5964.

  10. Xi, Y.; Wang, C.; Zhang, Q.; Qu, J.; Chen, Y.* Palladium-Catalyzed Regio-, Diastereo-, and Enantioselective1,2-Arylfluorination of Internal Enamides. Angew. Chem. Int. Ed. 2021, 60, 2699.

  11. Wu, X.; Qu, J.*; Chen, Y.*Quinim: a New Ligand Scaffold Enabled Nickel-Catalyzed Enantioselective Synthesis of α-Alkylated γ-Lactam. J. Am. Chem. Soc.2020, 142, 15646.

  12. Weng, Y.; Zhang, C.; Tang, Z.; Shrestha, M.; Huang, W.; Qu, J.*; Chen, Y.*Nickel-Catalyzed Allylic Carbonylative Coupling of Alkyl Zinc Reagents withtert-Butyl Isocyanide. Nat. Comm.2020, 11, 392.

  13. Chen, Y.; Huang, D.; Zhao, Y.; Newhouse, T. R.* Allyl-Palladium Catalyzed Ketone Dehydrogenation Enables Telescoping with Enone ,-Vicinal Difunctionalization. Angew. Chem. Int. Ed.2017, 56, 8258.

  14. Chen, Y.; Turlik, A.; Newhouse, T. R.* Amide Dehydrogenation Using Allyl-Palladium Catalysis and a Hindered Monodentate Anilide. J. Am. Chem. Soc. 2016, 138, 1166.

  15. Chen, Y.; Romaire, J. P.; Newhouse, T. R.* Palladium-Catalyzed Dehydrogenation of Esters and Nitriles. J. Am. Chem. Soc. 2015, 137, 5875.

  16. Chen, Y.; Chen, M.; Liu, Y.*Gold-Catalyzed Cyclization of 1,6-Diyne-4-en-3-ols: Stannyl Transferfrom2-Tributylstannylfuran Through Au/Sn Transmetalation. Angew. Chem. Int. Ed.2012,51, 6181.

  17. Chen, Y.; Chen, M.; Liu, Y.*Gold-Catalyzed Cascade Cyclizations of 1,6-Diynyl Carbonates to Benzo[b]fluorenes Involving Hydroarylation of Oxocarbenium Ion Intermediates and Decarboxylative Etherification. Angew. Chem. Int. Ed.2012, 51, 6493.

  18. Turlik, A.; Chen, Y.; Scruse, A. C.; Newhouse, T. R.* Convergent Total Synthesis of Principinol D, a Rearranged Kaurane Diterpenoid. J. Am. Chem. Soc. 2019, 141, 8088.

  19. Zhao, Y.; Chen, Y.; Newhouse, T. R.* Allyl-Palladium Catalyzed ,-Dehydrogenation of Carboxylic Acid via Enediolates. Angew. Chem. Int. Ed.2017, 56, 13122.

  20. Chen, M.; Chen, Y.; Sun, N.; Zhao, J. Liu, Y.*;Li, Y.* Gold-Catalyzed Oxidative Ring Expansion of 2-Alkynyl-1,2-Dihydropyridine or -quinolines: Highly Efficient Synthesis of Functionalized Azepine or Benzazepine Scaffolds. Angew. Chem. Int. Ed.2015,54, 1200.
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