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贺晓鹏


贺晓鹏,教授,博士生导师

国家基金委优秀青年科学基金获得者,上海市青年科技启明星

中国化学会高级会员,英国皇家化学会会士(FRSC

电话:86-21-64253016

地址:上海市徐汇区梅陇路130号华东理工大学实验十三楼406

邮箱:xphe@ecust.edu.cn

课题组主页:http://www.xphelab.com/


教育及工作经历:

2018–至今,华东理工大学,化学与分子工程学院,费林加诺贝尔奖科学家联合研究中心,教授(博士生导师)

2014–2018,华东理工大学,化学与分子工程学院,副研究员(20152017年分别获硕士和博士生导师资格)

2013–2014,华东理工大学,化学与分子工程学院,讲师

2011–2013,华东理工大学,化学与分子工程学院,博士后(合作导师:陈凯先院士)

2008–2009,法国Cachan高等师范学校,联合培养(导师:Prof. Juan Xie

2006–2011,华东理工大学,药学院,硕博连读(导师:施小新教授)

2002–2006,华东理工大学,化学与分子工程学院,本科


研究生招收专业:

博士第一招生专业:应用化学

博士第二招生专业:精细合成化学与分子工程

工程博士招生专业:生物与医药

硕士第一招生专业:应用化学

硕士第二招生专业:精细合成化学与分子工程

工程硕士招生专业:制药工程


诚挚欢迎对通过化学原理与技术探测生命与疾病过程中的关键科学问题,以及对研发具备我国自主知识产权,人类重大疾病诊治新试剂、新材料具有浓厚兴趣和探索精神的同学加入课题组!课题组与中科院上海药物研究所国家新药筛选中心,复旦大学附属中山医院,海军军医大学附属上海东方肝胆外科医院,上海交通大学药学院,上海交通大学附属仁济医院,天津医科大学,国家蛋白质中心,上海同步辐射光源,海军军医大学附属长海医院等国内顶尖生物医学团队建立跨学科合作平台,致力于培养、建立学生的交叉学科研究思维。课题组培养硕、博研究生中已有多人获上海市和校级优秀博士学位论文,研究生国家奖学金和成思危校长奖等各类荣誉奖励,课题组培养博士、博士后已有1人留校任教,1人受聘中科院上海药物所青年PI


学术兼职:

中国化学会糖化学专业委员会委员

Science Bulletin》、《高等学校化学学报》(中英文版)化学生物学青年执行编委

Frontiers in Chemistry-Supramolecular Chemistry Section副主编


荣誉和奖励:

英国皇家化学会会士(Fellow of the Royal Society of Chemistry)(2021

爱思唯尔2020中国高被引学者(2021

Thieme Chemistry Journals Award2020

中国化学会青年化学奖(2018

中国化学会化学生物学奖(35周岁以下突出贡献)(2018

国家自然科学基金优秀青年科学基金项目(2018–2020

上海市青年科技启明星计划(2016

上海市优秀博士学位论文(2013

华东理工大学优秀博士论文(2012

法国大使馆留学奖学金(2008


研究方向:

课题组长期致力于糖动态修饰与生物识别的原位化学探测,创制光控超高分辨标签和动态荧光阵列技术,为糖介导的重要生理病理过程原位精准探测与功能干预提供了新的化学策略。代表论文包括2Chem1Nat. Commun.2Sci. Bull., 7JACS3Angew. Chem. Int. Ed., 3Adv. Mater., 3Adv. Funct. Mater.10Chem. Soc. Rev.,所有论文被引用6000余次(H因子40)。多项研究工作被英国皇家化学会“Global challenges: Health & Food”专栏(该专栏旨在亮点介绍应对全球健康与食品重大挑战的优秀工作),美国C&EN(化学与工程新闻网)和Materials Views China等国际学术媒介亮点介绍。


近期代表性科研论文:

  1. W.-T. Dou, H.-H. Han, A. C. Sedgwick, G.-B. Zhu, Y. Zang, X.-R. Yang*, J. Yoon*, T. D. James*, J. Li*, X.-P. He*.Fluorescent probes for the detection of disease-associated biomarkers. Sci. Bull. 2022, DOI: 10.1016/j.scib.2022.01.014.

  2. W.-T. Dou, Z.-Y. Qin, J. Li, D.-M. Zhou, X.-P. He*. Self-assembled sialyllactosyl probes with aggregation-enhanced properties for ratiometric detection and blocking of influenza viruses. Sci. Bull. 2019, 64, 1902-1909.

  3. X.-P. He, H. Tian*. Lightening up Membrane Receptors with Fluorescent Molecular Probes and Supramolecular Materials. Chem 2018, 4, 246-268. (ESI highly cited paper; Invited review)

  4. J. Zhang, Y. Fu, H.-H. Han, Y. Zang, J. Li*, X.-P. He*, B. L. Feringa, H. Tian*. Remote Light-Controlled Intracellular Target Recognition by Photochromic Fluorescent Glycoprobes. Nat. Commun. 2017, 8, 987. (ESI highly cited paper; ESI hot paper; Highlighted by Sci. China Chem.)

  5. A. C. Sedgwick, K.-C. Yan, D. N. Mangel, Y. Shang, A. Steinbrueck, H.-H. Han, J. T. Brewster II, X.-L. Hu, D. W. Snelson, V. M. Lynch, H. Tian, X.-P. He*, J. L. Sessler*. Deferasirox (ExJade): An FDA-Approved AIEgen Platform with Unique Photophysical Properties. J. Am. Chem. Soc.  2021, 143, 1278-1283. (ESI highly cited paper)

  6. X. Chai, H.-H. Han, A. C. Sedgwick, N. Li, Y. Zang, T. D. James, J. Zhang*, X.-L. Hu, Y. Yu, Y. Li, Y. Wang, J. Li*, X.-P. He*, H. Tian. Photochromic Fluorescent Probe Strategy for the Super-resolution Imaging of Biologically Important Biomarkers. J. Am. Chem. Soc.  2020, 142, 18005-18013.

  7. J.-B. Jiao, G.-Z. Wang, X.-L. Hu, Y. Zang, S. Maisonneuve, A. C. Sedgwick, J. L. Sessler*, J. Xie*, J. Li*, X.-P. He*, H. Tian, Cyclodextrin-Based Peptide Self-Assemblies (Spds) That Enhance Peptide-Based Fluorescence Imaging and Antimicrobial Efficacy. J. Am. Chem. Soc. 2020, 142, 1925-1932.

  8. Z.-H. Yu, X. Li, F. Xu, X.-L. Hu, J. Yan, N. Kwon, G.-R. Chen, T. Tang, X. Dong, Y. Mai*, D. Chen*, J. Yoon*, X.-P. He*, H. Tian, A Supramolecular‐Based Dual‐Wavelength Phototherapeutic Agent with Broad Spectrum Antimicrobial Activity against Drug Resistant Bacteria. Angew. Chem. Int. Ed. 2020, 59, 3658-3664.

  9. A. C. Sedgwick, W.-T. Dou, J.-B. Jiao, L. Wu, G. T. Williams, A. T. A. Jenkins, S. D. Bull, J. L. Sessler*, X.-P. He*, T. D. James*, An ESIPT Probe for the Ratiometric Imaging of Peroxynitrite Facilitated by Binding to Aβ-Aggregates. J. Am. Chem. Soc. 2018, 140, 14267-14271.

  10. Y. Fu, H.-H. Han, J. Zhang*, X.-P. He*, B. L. Feringa, H. Tian*, Photo-Controlled Fluorescence “Double-Check” Bioimaging Enabled by a Glycoprobe-protein Hybrid. J. Am. Chem. Soc. 2018, 140, 8671-8674.

  11. Y. Huang, W.-T. Dou, F. Xu, H.-B. Ru, Q. Gong, D. Wu, D. Yan, H. Tian, X.-P. He*, Y. Mai*, X. Feng, Supramolecular Nanostructures of Structurally Defined Graphene Nanoribbons in Aqueous Phase. Angew. Chem. Int. Ed. 2018, 57, 3366-3371. (Very Important Paper)

  12. X.-P. He*, Y.-L. Zeng, X.-Y. Tang, N. Li, D.-M. Zhou*, G.-R. Chen, H. Tian*, Rapid Identification of the Receptor-Binding Specificity of Influenza A Viruses by Fluorogenic Glycofoldamers. Angew. Chem. Int. Ed. 2016, 55, 13995-13999. (ESI hot paper; Inside back cover)

  13. X.-P. He, X.-W. Wang, X.-P. Jin, H. Zhou, X.-X. Shi, G.-R. Chen, Y.-T. Long*, Epimeric Monosaccharide-Quinone Hybrids on Gold Electrodes toward the Electrochemical Probing of Specific Carbohydrate–Protein Recognitions. J. Am. Chem. Soc. 2011, 133, 3649-3657.

  14. H.-H. Han, H. Tian Jr., Y. Zang, A. C. Sedgwick, J. Li*, J. L. Sessler*, X.-P. He*, T. D. James*, Small-molecule fluorescence-based probes for interrogating major organ diseases. Chem. Soc. Rev. 2021, 50, 9391-9429.

  15. Steinbrueck, A. C. Sedgwick, J. T. Brewster II, K.-C. Yan, Y. Shang, D. M. Knoll, G. I. Vargas-Zúñiga, X.-P. He*, H. Tian*, J. L. Sessler*, Transition Metal Chelators, Pro-Chelators, and Ionophores as Small Molecule Cancer Chemotherapeutic Agents. Chem. Soc. Rev. 2020, 49, 3726-3747.

  16. A. C. Sedgwick, J. T. Brewster II, P. Harvey*, D. A. Iovan, G. Smith, X.-P. He*, H. Tian*, J. L. Sessler*, T. D. James*, Metal-Based Imaging Agents: Progress towards Interrogating Neurodegenerative Disease. Chem. Soc. Rev. 2020, 49, 2886-2915.

  17. ThomasK.-C. YanX.-L. HuM. Donnier-MaréchalG.-R. Chen*, X.-P. He*S. Vidal*, Fluorescent Glycoconjugates and Their Applications. Chem. Soc. Rev. 2020, 49, 593-641.

  18. J. Zhang, X. Chai, X.-P. He*, H.-J. Kim*, J. Yoon*, H. Tian, Fluorogenic Probes for Disease-Relevant Enzymes. Chem. Soc. Rev. 2019, 48, 683-722. (ESI highly cited paper)

  19. A. C. Sedgwick, L. Wu, H.-H. Han, S. D. Bull*, X.-P. He*, T. D. James*, J. L. Sessler*, B.- Z. Tang*, H. Tian*, J. Yoon*, Excited-State Intramolecular Proton-Transfer (ESIPT) Based Fluorescence Sensors and Imaging Agents. Chem. Soc. Rev. 2018, 47, 8842-8880. (ESI highly cited paper; ESI hot paper)

  20. X.-P. He*, X.-L. Hu, T. D. James*, J. Yoon*, H. Tian*, Multiplexed Photoluminescent Sensors: Towards Improved Disease Diagnostics. Chem. Soc. Rev. 2017, 46, 6687-6696. (Tutorial review)

  21. X.-P. He, Y. Zang, T. D. James*, J. Li*, G.-R. Chen*, J. Xie*, Fluorescent Glycoprobes: A Sweet Addition for Improved Sensing. Chem. Commun. 2017, 53, 82-90. (ESI highly cited paper; Feature article)

  22. X.-P. He, Y. Zang, T. D. James, J. Li*, G.-R. Chen*, Probing Disease-Related Proteins with Fluorogenic Composite Materials. Chem. Soc. Rev. 2015, 44, 4239-4248. (ESI highly cited paper; Tutorial review)

  23. X.-L. Hu, N. Kwon, K.-C. Yan, A. C. Sedgwick, G.-R. Chen, X.-P. He*, T. D. James*, J. Yoon*, Bio-Conjugated Advanced Materials for Targeted Disease Theranostics. Adv. Funct. Mater. 2020, 30, 1907906.

  24. X.-L. Hu, L. Chu, X. Dong, G.-R. Chen, T. Tang, D. Chen*, X.-P. He*, H. Tian, Multivalent Glycosheets for Double Light–Driven Therapy of Multidrug-Resistant Bacteria on Wounds. Adv. Funct. Mater. 2019, 29, 1806986.

  25. K.-C. Yan, A. C. Sedgwick, Y. Zang, G.-R. Chen, X.-P. He*, J. Li*, J. Yoon*, T. D. James*, Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases. Small Methods 2019, 3, 1900013.

  26. J.-X. Song, X.-Y. Tang, D.-M. Zhou*, W. Zhang, T. D. James, X.-P. He*, He Tian, A Fluorogenic 2D Glycosheet for the Simultaneous Identification of Human- and Avian-Receptor Specificity in Influenza Viruses. Mater. Horiz. 2017, 4, 431-436.

  27. Y.-H. Ma, W.-T. Dou, Y.-F. Pan, L.-W. Dong, Y.-X. Tan, X.-P. He*, H. Tian, H.-Y. Wang*, Fluorogenic 2D Peptidosheet Unravels CD47 as a Potential Biomarker for Profiling Hepatocellular Carcinoma and Cholangiocarcinoma Tissues. Adv. Mater. 2017, 29, 1604253. (ESI highly cited paper; Inside back cover)

  28. D.-K. Ji, Y. Zhang, Y. Zang, J. Li*, G.-R. Chen, X.-P. He*, H. Tian, Targeted Intracellular Production of Reactive Oxygen Species by a 2D Molybdenum Disulfide Glycosheet. Adv. Mater. 2016, 28, 9356-9363. (ESI hot paper)

  29. X.-P. He, H. Tian*, Photoluminescence Architectures for Disease Diagnosis: From Graphene to Thin-Layer Transition Metal Dichalcogenides and Oxides. Small 2016, 12, 144-160. (ESI highly cited paper; Highlighted by MaterialsViews China)

  30. J.-D. Zhang, J. Mei, X.-L. Hu, X.-P. He*, H. Tian, Ratiometric Detection of β‐Amyloid and Discrimination from Lectins by a Supramolecular AIE Glyconanoparticle. Small 2016, 12, 6562-6567.

  31. D.-K. Ji, G.-R. Chen, X.-P. He*, H. Tian, Simultaneous Detection of Diverse Glycoligand-Receptor Recognitions Using a Single-Excitation, Dual-Emission Graphene Composite. Adv. Funct. Mater. 2015, 25, 3483-3487.

  32. H.-L. Zhang, X.-L. Wei, Y. Zang, J.-Y. Cao, S. Liu, X.-P. He*, Q. Chen, Y.-T. Long, J. Li*, G.-R. Chen*, K. Chen, Fluorogenic Probing of Specific Recognitions between Sugar Ligands and Glycoprotein Receptors on Cancer Cells by an Economic Graphene Nanocomposite. Adv. Mater. 2013, 25, 4097-4101. (Front cover)



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