Guo-Rong CHEN

Key Laboratory for Advanced Materials & Institute of Fine Chemicals
School of Chemistry and Molecular Engineering

Contact Information
Office: Room 412, Researching Building 13
  Email: mrs_guorongchen@ecust.edu.cn
  Office Phone: +86 21 642 53016
  Office Fex: +86 21 642 52758
Education
1975.07 B.S. Organic Chemical Engineering, East China University of Science and Technology, P. R. China
Research Interests
Development of new optical and electrochemical biosensors based on nanomaterials (graphene, nanoparticles, etc.) for the study of the “Glycomics”
  Sugar-based drug discovery
  Construction of multi-functional compounds (Chemosensors, Corrosion inhibitors, etc.) by “Click Chemistry”
Professional Experience
1996, 1998, 2002   Sabbatical at Centre Nationale de la Recherche Scientifique, Lyon, France
  1992-1994              Sabbatical, invited by prof. Yuyuan Xie, CAS academician
  1992-1994              Sabbatical, invited by prof. Yuyuan Xie, CAS academician
                                 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica
                                 Chinese Academy of Sciences                                
  1989-1991              Sabbatical, supported by the Chinese Ministry of Education                               Nationale de la Recherche Scientifique, Lyon, France
   2003-now              Full professor of the Institute of Fine Chemicals
                                 East China University of Science & Technology, Shanghai, CHINA
Group Members

Researchers:
  Prof. Dr. Yan-Hui TANG
  Dr. Xiao-Peng HE

Ph.D. Students:
  De-Tai SHI
  Zhen LI
  Chao-Ying CHENG
  Kai-Bin LI

Publications
1. H.-L. Zhang, X.-L. Wei, Y. Zang, J.-Y. Cao, S. Liu, X.-P. He, Q. Chen, Y.-T. Long, J. Li, G.-R. Chen, K. Chen, Fluorogenic probing of specific recognitions between sugar ligands and       glycoprotein receptors on cancer cells by an economic graphene nanocomposite. Adv. Mater., 2013, doi: 10.1002/adma.201300187 (Front Cover)
  2. D.-T. Shi, B. Zhang, Y.-X. Yang, C.-C. Guan, X.-P. He, Y.-C. Li, G.-R. Chen, K. Chen, Bis-triazolyl indoleamines as unique “off-approach-on” chemosensors for copper and fluorine.
  Analyst, 2013, 138, 2808.

3. X.-P. He, J. Xie, Y. Tang, J. Li, G.-R. Chen, CuAAC click chemistry accelerates the discovery of novel chemical scaffolds as promising protein tyrosine phosphatases inhibitors.
  Curr. Med. Chem., 2012, 19, 2399. (Invited Review)

4. Q. Deng, X.-P. He, H.-W. Shi, B.-Q. Chen, G. Liu, Y. Tang, Y.-T. Long, G.-R. Chen, K. Chen, Concise CuI-catalyzed azide-alkyne 1,3-dipolar cycloaddition reaction ligation remarkably enhances the corrosion inhibitive potency of natural amino acids for mild steel in HCl.
  Ind. Eng. Chem. Res., 2012, 51, 7160.

5. Q. Deng, N.-N. Ding, X.-L. Wei, L. Cai, X.-P. He, Y.-T. Long, G.-R. Chen, Identification of diverse 1,2,3-triazole-connected benzyl glycoside-serine/threonine conjugates as potent corrosion inhibitors for mild steel in HCl. Corros. Sci., 2012, 64, 64.

6. Q. Deng, H.-W. Shi, N.-N. Ding, B.-Q. Chen, X.-P. He, G. Liu, Y. Tang, Y.-T. Long, G.-R. Chen, Novel triazolyl bis-amino acid derivatives readily synthesized via click chemistry as potential corrosion inhibitors for mild steel in HCl. Corros. Sci., 2012, 57, 220.

7. Y.-H. Tang, Y. Qu, Z. Song, X.-P. He, J. Xie, J. Hua, G.-R. Chen, Discovery of a sensitive Cu(II)-cyanide “off-on” sensor based on new C-glycosyl triazolyl bis-amino acid scaffold.
  Org. Biomol. Chem., 2012, 10, 555.

8. X.-P. He, X.-W. Wang, X.-P. Jin, H. Zhou, X.-X. Shi, G.-R. Chen, Y.-T. Long, Epimeric monosaccharide-quinone hybrids on gold electrodes toward the electrochemical probing of specific carbohydrate-protein recognitions. J. Am. Chem. Soc., 2011, 133, 3649.

9. Y.-J. Zhang, W. Dayoub, G.-R. Chen, M. Lemaire, Environmentally benign metal triflate-catalyzed reductive cleavage of the C-O bond of acetals to ethers.
  Green Chem., 2011, 13, 2737.

10. Y.-J. Zhang, X.-P. He, M. Hu, Z. Li, X.-X. Shi, G.-R. Chen, Highly optically selective and electrochemically active chemosensor for copper (II) based on triazole-linked glucosyl anthraquinone. Dyes Pigments, 2011, 88, 391.

11. X.-P. He, Z. Song, Z.-Z. Wang, X.-X. Shi, K. Chen, G.-R. Chen, Creation of 3,4-bis-triazolocoumarin-sugar conjugates via fluorogenic dual click chemistry and their quenching specificity with silver(I) in aqueous media. Tetrahedron, 2011, 67, 3343.

12. X.-P. He, Q. Deng, L.-X. Gao, C. Li, W. Zhang, Y.-B. Zhou, Y. Tang, X.-X. Shi, J. Xie, J. Li, G.-R. Chen, K. Chen, Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on ‘clicked’ serine/threonine-monosaccharide hybrids. Bioorg. Med. Chem., 2011, 19, 3892.

13. C. Li, X.-P. He, Y.-J. Zhang, Z. Li, L.-X. Gao, X.-X. Shi, J. Xie, J. Li, G.-R. Chen, Y. Tang, Click to a focused library of benzyl 6-triazolo(hydroxy)bezoic glucosides: Novel construction of PTP1B inhibitors on a sugar scaffold. Eur. J. Med. Chem., 2011, 46, 4212.
  14. S.-X. Song, H.-L. Zhang, C.-G. Kim, L. Sheng, X.-P. He, Y.-T. Long, J. Li, G.-R. Chen, Expeditious preparation of triazole-linked glycolipids via microwave accelerated click chemistry and their electrochemical and biological assessments.  Tetrahedron, 2010, 66, 9974.

15. Y. Shi, W. Dayoub, G.-R. Chen, M. Lemaire, Selective synthesis of 1-O-alkyl glycerol and diglycerol ethers by reductive alkylation of alcohols. Green Chem., 2010, 12, 2189.